Abstract:
CONTEXT:Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. OBJECTIVE:To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multiple myeloma cells. MATERIALS AND METHODS:Compounds were obtained from the EtOAc extract of W. adpressa leaves. Structure elucidation was carried out mainly by 1D- and 2D-NMR, and mass spectrometry. Isolated compounds were tested in a dose-response for their in vitro NF-κB inhibition and antiproliferative activity in multiple myeloma cells after 5 and 72 h treatment, respectively. RESULTS:The fractionation resulted in the isolation of a new glycowithanolide named wadpressine (5) together with withanolide F, withaferin A, coagulin L, and nicotiflorin. The latter showed a moderate ability to scavenge free radicals in DPPH (IC50 = 35.3 µM) and NO (IC50 = 41.3 µM) assays. Withanolide F and withaferin A exhibited low µM antiproliferative activity against both multiple myeloma cancer stem cells and RPMI 8226 cells. Furthermore, they inhibited NF-κB activity with IC50 values of 1.2 and 0.047 µM, respectively. The other compounds showed a moderate inhibition of cell proliferation in RPMI 8226 cells, but were inactive against cancer stem cells and did not inhibit NF-κB activity. DISCUSSION AND CONCLUSIONS:One new glycowithanolide and four known compounds were isolated. Biological evaluation data gave further insight on the antitumor potential of withanolides for refractory cancers.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Ben Bakrim W,El Bouzidi L,Nuzillard JM,Cretton S,Saraux N,Monteillier A,Christen P,Cuendet M,Bekkouche Kdoi
10.1080/13880209.2018.1499781subject
Has Abstractpub_date
2018-12-01 00:00:00pages
505-510issue
1eissn
1388-0209issn
1744-5116journal_volume
56pub_type
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2019.1687527
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doi:10.1080/13880209.2020.1844760
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abstract::A model for a database system that provides a standardized environment for submission, storage, and retrieval of ethnomedicinal data was developed. The model is based on object oriented database technology, and is suitable for not only storing data, digital images, sound and video, but also for modeling domain knowled...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2016.1145700
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journal_title:Pharmaceutical biology
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doi:10.1080/13880209.2016.1265986
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Pharmaceutical biology
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.523006
更新日期:2011-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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更新日期:2011-08-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:2000-01-01 00:00:00
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