Abstract：
CONTEXT:Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE:Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS:Thirty male Wistar rats (7-8 weeks old) were randomly assigned to five groups (n = six per group). Treatment groups were administered with 1, 5 and 10 g/kg VCO for 31 days by oral gavages. The cognitive function of treated-rats were assessed using the Morris Water Maze Test. Brains were removed, homogenized and subjected to biochemical analyses of acetylcholine (ACh) and acetylcholinesterase (AChE), antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GRx)], lipid peroxidase [malondialdehyde (MDA)] as well as nitric oxide (NO). α-Tocopherol (αT; 150 mg/kg) was also included for comparison purposes. RESULTS:VCO-fed Wistar rats exhibited significant (p < 0.05) improvement of cognitive functions [reduced escape latency (≥ 1.8 s), reduced escape distance (≥ 0.3 m) and increased total time spent on platform (≥ 1 s)]. The findings were accompanied by elevation of ACh (15%), SOD (8%), CAT (≥ 54%), GSH (≥ 20%) and GPx (≥ 12%) and reduction of AChE (≥17%), MDA (> 33%) and NO (≥ 34%). Overall, memory improvement by VCO was comparable to αT. DISCUSSION AND CONCLUSION:VCO has the potential to be used as a memory enhancer, the effect of which was mediated, at least in part, through enhanced cholinergic activity, increased antioxidants level and reduced oxidative stress.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Rahim NS,Lim SM,Mani V,Abdul Majeed AB,Ramasamy Kdoi
10.1080/13880209.2017.1280688subject
Has Abstractpub_date
2017-12-01 00:00:00pages
825-832issue
1eissn
1388-0209issn
1744-5116journal_volume
55pub_type
杂志文章abstract：CONTEXT:Bombacaceae is a small family of the order Malvales and contains about 28 genera and 200 species. Members of this family are not only showy ornamentals but they possess significant economical and commercial reputation as well. In addition, various plant parts of several species are widely used as foods and trad...
journal_title：Pharmaceutical biology
pub_type： 杂志文章,评审
doi：10.3109/13880209.2012.698286
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pub_type： 杂志文章
doi：10.1080/13880209.2020.1835996
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abstract：CONTEXT:Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property. OBJECTIVE:Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl(4))-induced liver damage in rats were investigated. MATERIALS...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2011.604335
更新日期：2012-03-01 00:00:00
abstract：CONTEXT:Tagetes patula L. is one of the French marigold group of the Asteraceae family. It is recognized in folklore for its medicinal and pesticidal properties. OBJECTIVE:In search of more effective, but non-toxic compounds with antioxidative potential led to the bioassay guided isolation studies on the extracts of T...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2010.523006
更新日期：2011-05-01 00:00:00
abstract：CONTEXT:Vicenin-1, a flavonol glycoside, has potent platelet aggregation inhibition, antioxidant, radioprotectants and anti-inflammatory activities. OBJECTIVE:To establish a rapid, simple, precise and sensitive high-performance liquid chromatography (HPLC) method for determination of vicenin-1 in rat plasma, and to in...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2016.1172245
更新日期：2016-11-01 00:00:00
abstract：:Context:Mitrephora sirikitiae Weeras., Chalermglin & R.M.K. Saunders (Annonaceae) is a plant endemic to Thailand. Its constituents and their biological activities are unknown.Objective: Isolation and identification of the compounds in the leaves and stems of M. sirikitiae and determination of their cytotoxicity.Materi...
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pub_type： 杂志文章
doi：10.1080/13880209.2020.1765813
更新日期：2020-12-01 00:00:00
abstract：CONTEXT:The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries. OBJECTIVE:Our present study investigated the hypouricemic effect of the methanol extract from P. mume fruit (MPMF) in mice with potassium...
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pub_type： 杂志文章
doi：10.3109/13880209.2012.683115
更新日期：2012-11-01 00:00:00
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journal_title：Pharmaceutical biology
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更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
doi：10.3109/13880209.2013.836544
更新日期：2014-03-01 00:00:00
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journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2012.716851
更新日期：2013-02-01 00:00:00
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abstract：UNLABELLED:Abstract Context: Solute carrier transporters (SLCs) are membrane proteins responsible for cellular influx of various substances including many pharmaceutical agents; therefore, they largely impact on drug disposition and elimination in body. Punica granatum Linnaeus (Lythraceae), pomegranate, is a fruit wit...
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pub_type： 杂志文章
doi：10.3109/13880209.2014.900809
更新日期：2014-12-01 00:00:00
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doi：10.1080/13880209.2019.1703756
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pub_type： 杂志文章
doi：10.3109/13880209.2011.574707
更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
doi：10.3109/13880209.2013.877492
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
doi：10.3109/13880209.2015.1063673
更新日期：2016-07-01 00:00:00
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更新日期：2014-10-01 00:00:00
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更新日期：2020-12-01 00:00:00
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doi：10.3109/13880209.2012.655858
更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
doi：10.3109/13880209.2010.523429
更新日期：2011-05-01 00:00:00
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更新日期：2020-12-01 00:00:00
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更新日期：2016-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
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journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2016.1263344
更新日期：2017-12-01 00:00:00
