Abstract:
CONTEXT:Peripheral axon injury and degeneration are often mediated by oxidative stress and inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great attention because of its antioxidant and anti-inflammatory activities. OBJECTIVE:The objective of this work is to study the effect of HERP on nerve repair and functional recovery after sciatic nerve injury (SNI) in rats. MATERIALS AND METHODS:The chemical markers in HERP were identified using high-resolution mass spectroscopy. After axonotmesis of sciatic nerve, ibuprofen (IBP) and HERP treatments were orally administered for 28 d. Behavioural tests were performed weekly after SNI. The myelinated axon number was counted using morphometric analysis. RESULTS:The compounds found in HERP were pinocembrin, formononetin, vestitol, and biochanin A. The animals that underwent SNI showed a significant decrease in motor function based on the Basso, Beattie and Bresnahan scale and sciatic functional index compared with sham animals until 7 d after the surgery (p < 0.05). After 14 and 21 d, the SNI groups treated with either HERP or IBP showed significant improvement (p < 0.01), and the SNI group treated with HERP 10 mg/kg showed accelerated motor recovery compared with the other groups (p < 0.01). SNI caused also a reduction in the myelinated axon counts, and treatment with HERP 10 mg/kg induced a significant increase in the number of myelinated fibres compared with all other groups. CONCLUSION:HERP promoted regenerative responses and accelerated functional recovery after sciatic nerve crush. Thus, it can be considered to be a new strategy or complementary therapy for treating nerve injuries.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Barbosa RA,Nunes TL,Nunes TL,da Paixão AO,Belo Neto R,Moura S,Albuquerque Junior RL,Cândido EA,Padilha FF,Quintans-Júnior LJ,Gomes MZ,Cardoso JCdoi
10.3109/13880209.2015.1091844subject
Has Abstractpub_date
2016-01-01 00:00:00pages
993-1004issue
6eissn
1388-0209issn
1744-5116journal_volume
54pub_type
杂志文章abstract:CONTEXT:Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation. OBJECTIVE:This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protectiv...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.957782
更新日期:2015-07-01 00:00:00
abstract:CONTEXT:Chrysanthemum boreale Makino (Compositae) (CBM) is a traditional medicine that has been used for the prevention or treatment of various disorders; it has various properties including antioxidation, anti-inflammation, and antitumor. OBJECTIVE:The present study was designed to explore the in vitro effect of CBM ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.941882
更新日期:2015-05-01 00:00:00
abstract:CONTEXT:Tournefortia sarmentosa Lam. (Boraginaceae), a Chinese herbal medicine, is commonly used as a detoxicant or anti-inflammatory agent. OBJECTIVE:As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T. sarmentosa on APAP-induced hepatotoxicity in vivo and i...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.602695
更新日期:2012-03-01 00:00:00
abstract:CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.542761
更新日期:2011-07-01 00:00:00
abstract::Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Material...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2019.1701042
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:The Boraginaceae family comprises plants that have important therapeutic and cosmetic applications. Their pharmacological effect is related to the presence of naphthaquinones, flavonoids, terpenoids, phenols, or purine derivative - allantoin. OBJECTIVE:In the present study, comparison of some secondary metabol...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1265986
更新日期:2017-12-01 00:00:00
abstract::Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.Objective: To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1720745
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Hyperthermia causes detrimental effects on the testes leading to fertility problems. Mallotus roxbhurghianus Muell. Arg. (Euphorbiaceae) is used in traditional medicine and possesses antioxidant property. However, the mechanisms remain unknown in the context of alleviative action of M. roxburghianus against hea...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1091480
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects. OBJECTIVE:Gossypol...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2013.832776
更新日期:2014-01-01 00:00:00
abstract:CONTEXT:Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centu...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2011.558515
更新日期:2011-09-01 00:00:00
abstract:CONTEXT:Scutellaria baicalensis Georgi (Lamiaceae) is a popular medicinal plant. Its roots are used as the famous traditional Chinese medicine Huang-Qin, which is recorded in Chinese Pharmacopoeia, European Pharmacopoeia, and British Pharmacopoeia. OBJECTIVE:This review comprehensively summarizes research progress in ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.1080/13880209.2018.1492620
更新日期:2018-12-01 00:00:00
abstract:CONTEXT: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations. OBJECTIVES: To investigate the antioxidant (in vitro and in vivo) and drug detoxification potential of aqueous extract of A. senegalensis...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.483247
更新日期:2010-12-01 00:00:00
abstract::Essential oil compositions and antioxidant potentials of fourteen ethanol (75%) root extracts prepared from twelve taxa of the genus Paeonia (Paeoniaceae), including P. arietina Anders., P. daurica Andrews, P. xkayae N. Ozhatay, P. kesrouanensis Thiéb., P. mascula (L.) Miller subsp. arasicola G. Kaynak, ö. Yilmaz & R....
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903029332
更新日期:2010-01-01 00:00:00
abstract:CONTEXT:Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of a variety of cancers. Crocus sativus (Iridaceae), which has been used as a folk medicine for treating diseases for ages, showed obviou...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2013.771190
更新日期:2013-07-01 00:00:00
abstract:CONTEXT:The possibility of combining unripe plantain [Musa paradisiacae Linn (Plantaginaceae)] and cocoyam [Colocassia esculenta Linn (Araceae)] in the management of diabetes has not been investigated. OBJECTIVE:The objective of this study is to evaluate the antihyperglycemic and antihyperlipidemic actions of unripe p...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1016181
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. OBJECTIVE:This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)-...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1103753
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Epidioxy sterols and sterols with special side chains, such as hydroperoxyl sterols, usually obtained from marine natural products, are attractive for bioactivities. OBJECTIVE:To isolate and screen bioactive and special sterols from China Sea invertebrates. MATERIALS AND METHODS:Two hydroperoxyl sterols (1 an...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.821664
更新日期:2014-02-01 00:00:00
abstract:CONTEXT:Uncaria tomentosa D.C. (Rubiaceae) has several biological activities, including activity against resistant Candida strains. The synergistic interaction with terbinafine or fluconazole can be an important alternative to overcome this resistance. OBJECTIVES:The potential synergy between a water insoluble fractio...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1242631
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.846916
更新日期:2013-12-13 00:00:00
abstract:CONTEXT:The extraction method and the crude wound healing effects of sacchachitin from Ganoderma tsugae Murr. (Ganodermataceae) has been cited. However, its purity is still largely limited. OBJECTIVE:An improvement of the fractionation protocol to purify the sacchachitin from Ganoderma lucidum L. (Ganodermataceae) (SG...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract:CONTEXT:The medicinal plants used in the traditional medicine of Rivers State of Nigeria were surveyed. OBJECTIVE:The survey aims to identify and document the plants used amongst the indigenes of Rivers State. MATERIALS AND METHODS:Semi-structured interviews were conducted during a field trip to gather information fr...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.661740
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models. METHODS:The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, e...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.486407
更新日期:2010-12-01 00:00:00
abstract::Eugenia jambolana Lam. (Myrtaceae) is widely used in folk medicine as an antidiabetic, but there is a lack of information about its toxicity, especially for the stem bark. The present study evaluated acute oral and repeated-dose toxicity of the stem bark aqueous extract of Eugenia jambolana (EJ) in albino mice and Wis...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903300204
更新日期:2010-08-01 00:00:00
abstract:CONTEXT:Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. OBJECTIVE:This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. MATERIALS AND METHODS:The pharmacokinetics of orally administered anastrozole (...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2018.1501584
更新日期:2018-12-01 00:00:00
abstract:CONTEXT:Ageratum conyzoides Linn. (Asteraceae) is an annual herbaceous plant with a long history of traditional medicinal and agricultural uses; it is usually grown in the northeast part of Bangladesh. OBJECTIVE:The ethanol extract of the plant leaves was evaluated for preliminary phytochemical screening with its anti...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.770535
更新日期:2013-07-01 00:00:00
abstract:CONTEXT:Ferula cupularis (Boiss.) Spalik et S. R. Downie (Apiaceae) is a common plant in Iran that grows in the foothills of Dena Mountain. In traditional folk medicine, this plant has different applications, but there are no studies proving their uses. OBJECTIVE:This study is the first attempt to investigate the chem...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.924149
更新日期:2015-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1784234
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE:This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1304427
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Several studies have demonstrated that essential oils and their major components have antioxidant activity. p-Cymene is a monoterpene and a major constituent of essential oils of various species of plants. OBJECTIVE:This paper evaluated the antioxidant potential of p-cymene in the hippocampus of mice by determ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.923003
更新日期:2015-03-01 00:00:00
abstract:CONTEXT:Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. OBJECTIVE:Terminalia ch...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.962058
更新日期:2015-08-01 00:00:00