Abstract：
:Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Materials and methods: The SHI-1 cells (1 × 106 cells in 0.1 mL PBS) were injected subcutaneously into the right flanks of the female SCID mice. Curcumin dissolved in olive oil (15 and 30 mg/kg) was administered (i.p.) to mice once a day for 15 days while the control group received olive oil injection. Tumour proliferation and apoptosis were examined by PCNA, TUNEL and cleaved caspase-3 staining. The expression of MAPK, NF-κB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg). Curcumin inhibited the expression of PCNA and increased the degree of TUNEL and cleaved caspase-3 staining in tumour tissue. The results of western blotting showed that curcumin treatment inhibited NF-κB and ERK signalling while activating p38 and JNK. Moreover, curcumin attenuated the mRNA transcription and protein expression of MMP2 and MMP9. Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Zhu G,Shen Q,Jiang H,Ji O,Zhu L,Zhang Ldoi
10.1080/13880209.2019.1701042subject
Has Abstractpub_date
2020-12-01 00:00:00pages
25-34issue
1eissn
1388-0209issn
1744-5116journal_volume
58pub_type
杂志文章abstract：CONTEXT:Sepsis continues to be a significant problem for critical care patients. OBJECTIVE:To evaluate the protective effects of IgM-enriched immunoglobulin and erythropoietin on pulmonary and small intestine tissues in a rat model of intra-abdominal sepsis induced via the cecal ligation and puncture (CLP) method. MA...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2014.910535
更新日期：2015-01-01 00:00:00
abstract：CONTEXT:A previous study demonstrated that the chloroform extract of Salvia connivens Epling (Lamiaceae) has anti-inflammatory activity. OBJECTIVE:Identification of the active components in the dicholorometane extract (DESC), and, standardization of the extract based in ursolic acid. MATERIAL AND METHODS:DESC was pre...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2017.1305423
更新日期：2017-12-01 00:00:00
abstract：CONTEXT:Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is widely used in tribal medicine in India and some other countries for multiple clinical applications. It contains andrographolide (AG) (diterpenoid lactone), a major phytomarker which probably accounts for its medicinal properties. OBJECTIVE:This study inv...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2013.836544
更新日期：2014-03-01 00:00:00
abstract：CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2010.548390
更新日期：2011-08-01 00:00:00
abstract：CONTEXT:Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. OBJECTIVE:This study evaluated the effects of methanol extracts ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2015.1067232
更新日期：2016-07-01 00:00:00
abstract：CONTEXT:Tournefortia sarmentosa Lam. (Boraginaceae), a Chinese herbal medicine, is commonly used as a detoxicant or anti-inflammatory agent. OBJECTIVE:As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T. sarmentosa on APAP-induced hepatotoxicity in vivo and i...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2011.602695
更新日期：2012-03-01 00:00:00
abstract：CONTEXT:There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects. OBJECTIVE:To extract Bocfal EO, to identify and quantify its ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2016.1258424
更新日期：2017-12-01 00:00:00
abstract：:Different extracts from the stem bark of Berberis asiatica L. , a plant traditionally used to hasten the process of wound healing, and the alkaloid fractions derived from the commonly used aqueous extract, were tested for their putative antimicrobial activity against a battery of microorganisms by disk diffusion and a...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1076/1388-0209(200009)3841-AFT254
更新日期：2000-01-01 00:00:00
abstract：CONTEXT:For years, natural products from microbes have been used as drugs. Endophytes are the most important fungi that produce many novel metabolites for potential use in pharmacology and agriculture. OBJECTIVE:The objective of the present study was to explore new endophytes for novel natural products. MATERIALS AND...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2014.910673
更新日期：2015-01-01 00:00:00
abstract：:Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl-5-[2',3',4'-trihydroxy-6'-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3'-tri...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880200903273898
更新日期：2010-07-01 00:00:00
abstract：CONTEXT:Chrysanthemum boreale Makino (Compositae) (CBM) is a traditional medicine that has been used for the prevention or treatment of various disorders; it has various properties including antioxidation, anti-inflammation, and antitumor. OBJECTIVE:The present study was designed to explore the in vitro effect of CBM ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2014.941882
更新日期：2015-05-01 00:00:00
abstract：CONTEXT:Zhi-Zi-Hou-Pu decoction (ZZHPD) is a traditional prescription which has been used to treat "Yu-syndrome" (depression and melancholia) in Chinese herbal medication. OBJECTIVE:To evaluate antidepressant activities of ZZHPD, its fractions and possible mechanism(s) of action. MATERIALS AND METHODS:ZZHPD (1241, 24...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2012.717087
更新日期：2013-02-01 00:00:00
abstract：CONTEXT:The pharmaceutical alkaloid huperzine A (HupA), currently used in herbal supplements and medicines worldwide, is predominantly sourced from the Chinese lycopod Huperzia serrata (Thunb. ex Murray) Trev. (Lycopodiaceae), which on average contains only 0.08 mg HupA g(-1) dry weight, and is experiencing a rapid dec...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2010.485619
更新日期：2010-09-01 00:00:00
abstract：:Context Worldwide ethnobotanical research has shown the importance of home gardens as sources of medicinal plants. These resources are worthy of further study in the Argentinean Atlantic Forest due to the richness of medicinal flora and their importance for local people. Objective We studied richness, composition, cul...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2015.1110600
更新日期：2016-09-01 00:00:00
abstract：:Breast cancer (BCa) is the most commonly occurring cancer in women, comprising almost one third of all malignancies. Previously we reported that the n-hexane fraction (hSL) of the Siddha herbal medicine, Semecarpus Lehyam, relatively sensitized estrogen receptor-negative (ER(-)) BCa when compared to estrogen receptor-...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880200902942410
更新日期：2009-09-01 00:00:00
abstract：:Rhinacanthus nasutus (L.) Kurz (Acanthaceae) has long been used in Thai traditional medicine for treatment of tinea versicolor, ringworm, pruritic rash, and abscess. The active constituents are known as a group of naphthoquinone esters, rhinacanthins. This work focused on establishment of R. nasutus root cultures and ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880200903578747
更新日期：2010-11-01 00:00:00
abstract：CONTEXT:Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus (DM). The availability of multiple lipid-lowering drugs and supplements provides new opportunities for patients to regulate lipid levels. OBJECTIVE:The present study was designed to evaluate the effect of Butea monosp...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2013.876055
更新日期：2014-08-01 00:00:00
abstract：CONTEXT:Amaranthus spinosus Linn. (Amaranthaceae), commonly known as ''spiny pigweed'', is used in both Indian traditional system and folk medicine for treatment of infectious diseases for a long time in several traditional herbal medicinal preparations. A novel fatty acid [(14E, 18E, 22E, 26E)-methyl nonacosa-14, 18, ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2016.1155628
更新日期：2016-10-01 00:00:00
abstract：CONTEXT:Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE:This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2017.1371770
更新日期：2017-12-01 00:00:00
abstract：CONTEXT:Cassia fistula Linn. (Caesalpiniaceae) has been used in folk medicine. Anthraquinone derivative rhein having antimicrobial properties is actively present in C. fistula fruit. Although, as yet there has been no study of its anticandidal potential. OBJECTIVE:The present study was conducted to determine the phyto...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2010.544318
更新日期：2011-07-01 00:00:00
abstract：CONTEXT:The roots of Phytolacca americana L. (Phytolaccaceae) may be toxic. Despite heated controversy over the toxic compounds of P. americana, especially esculentosides, relevant studies remain scarce. OBJECTIVE:The objective of this study is to screen the toxic fractions and compounds of P. americana, to determine ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2015.1016182
更新日期：2016-01-01 00:00:00
abstract：:Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a causative agent of liver inflammation that may lead to fibrosis and hepato-carcinoma. In this study, we investigated the anti...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2020.1750658
更新日期：2020-12-01 00:00:00
abstract：CONTEXT:Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae). OBJECTIVE:The present study investigated the effect of citronellal on inflammatory nociception induced by different stimuli and examined the involvement of the NO-cGMP-ATP-sensitive K⁺ channel pa...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2013.781656
更新日期：2013-09-01 00:00:00
abstract：CONTEXT:Silymarin (SM) is extracted from milk thistle Silybum marianum L. [Asteraceae (Compositae)] and known for antioxidative and anti-inflammatory effects. OBJECTIVE:The potential antidepressant-like effect of acute SM and possible involvement of nitric oxide (NO) were determined in male mice. MATERIAL AND METHODS...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2014.942787
更新日期：2015-05-01 00:00:00
abstract：CONTEXT:Felicia muricata Thunb. (Nees) (Asteraceae) leaves are used in folklore medicine of South Africa as an oral remedy for pain and inflammation. However, the efficacy of the plant part is yet to be validated with scientific experiments. OBJECTIVE:The current study is an effort to investigate the anti-inflammatory...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880200903373664
更新日期：2010-09-01 00:00:00
abstract：:Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in the clinic. Objective To determine the neuroprotective effect of SMI, we investigated the effect...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2016.1155625
更新日期：2016-10-01 00:00:00
abstract：CONTEXT:The genus Hypericum (Guttiferae) has received considerable scientific interest as a source of biologically active compounds. OBJECTIVE:The study determined the morphogenetic and ontogenetic variation in the main bioactive compounds of two Hypericum species, namely, Hypericum aviculariifolium subsp. depilatum v...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2012.733012
更新日期：2013-03-01 00:00:00
abstract：:Context: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug-drug interaction between puerarin and triptolide is still unknown. Objective: This study investigates the effects of puerarin on the pharmacokinetics of triptolide in rats and clarifies its m...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880209.2019.1626448
更新日期：2019-12-01 00:00:00
abstract：CONTEXT:Granulocyte colony stimulating factor (G-CSF) has been commonly used to treat neutropenia caused by chemotherapy, radiotherapy, and organ transplants. Improved in vitro efficacy of G-CSF has already been observed by conjugating it to polyethylene glycol (PEG). OBJECTIVE:The in vivo bioassay using tetrazolium d...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.3109/13880209.2014.943248
更新日期：2015-06-01 00:00:00
abstract：:The in vitro. antifungal activity of the aqueous, ethanol, chloroform, petroleum ether, and residue extracts from 10 indigenous Bahraini plants used in folk medicine for the treatment of various diseases is reported. Extract efficacy was evaluated using the agar well diffusion assay against four filamentous fungi and ...
journal_title：Pharmaceutical biology
pub_type： 杂志文章
doi：10.1080/13880200590951766
更新日期：2005-01-01 00:00:00
