Abstract:
:Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Eugenio-Pérez D,Montes de Oca-Solano HA,Pedraza-Chaverri Jdoi
10.3109/13880209.2016.1150302subject
Has Abstractpub_date
2016-10-01 00:00:00pages
2340-52issue
10eissn
1388-0209issn
1744-5116journal_volume
54pub_type
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