Abstract:
CONTEXT:Cancer chemopreventive action of walnut [Juglans regia L. (Juglandaceae)] has been explored. OBJECTIVE:This study evaluated antiproliferative and antioxidant activities of walnut. MATERIALS AND METHODS:Various fractions of walnut extract have been screened for antiproliferative activity against human cancer cell lines using the MTT assay. All these fractions have also been evaluated for total phenolic content, antioxidant activity, and reducing power capacity. RESULTS AND DISCUSSION:Chloroform and ethyl acetate fractions exhibited a high level of antiproliferation against HepG-2, liver cancer cell line (IC(50) = 9 and 15 µg/mL, respectively). CONCLUSION:Exhibiting high phenolic content, antioxidant activity, and potent antiproliferative activity, walnut may act as a cancer chemopreventive agent.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Negi AS,Luqman S,Srivastava S,Krishna V,Gupta N,Darokar MPdoi
10.3109/13880209.2010.537666subject
Has Abstractpub_date
2011-06-01 00:00:00pages
669-73issue
6eissn
1388-0209issn
1744-5116journal_volume
49pub_type
杂志文章abstract::Proteins from Parkia speciosa Hassk. (Fabaceae) seeds were extracted and stepwise precipitated using ammonium sulfate. Proteins precipitated with 25% ammonium sulfate were separated by affinity chromatography on Affi-Gel Blue gel followed by protein liquid chromatography on Superdex 200. The protein Gj, which was iden...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903046195
更新日期:2010-01-01 00:00:00
abstract::Context Worldwide ethnobotanical research has shown the importance of home gardens as sources of medicinal plants. These resources are worthy of further study in the Argentinean Atlantic Forest due to the richness of medicinal flora and their importance for local people. Objective We studied richness, composition, cul...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1110600
更新日期:2016-09-01 00:00:00
abstract:CONTEXT:The incidence and mortality of thrombotic disorders are rapidly increasing throughout the world. Therefore, attempts have been made to develop new anticoagulant and antithrombotic drugs. Our previous studies showed that a novel protein, named Fu-P, had fibrinogenolytic activity and much higher fibrinolytic acti...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.641023
更新日期:2012-07-01 00:00:00
abstract::Context Gelidiella acerosa (Forsskål) Feldmann & G. Hamel (Rhodophyta-Gelidiales) is a marine red macroalga. Our previous work found that a benzene extract of G. acerosa possesses noticeable neuroprotective activity, when evaluated through in vitro and in vivo systems. Objective Bioactive-guided fractionation and iden...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1145700
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. OBJECTIVE:To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. MATERIALS AND METHODS:Cyanobacteria were collected from Las Perlas Archipelago, Panama and...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1181659
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:The genus Hypericum (Guttiferae) has received considerable scientific interest as a source of biologically active compounds. OBJECTIVE:The study determined the morphogenetic and ontogenetic variation in the main bioactive compounds of two Hypericum species, namely, Hypericum aviculariifolium subsp. depilatum v...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.733012
更新日期:2013-03-01 00:00:00
abstract:CONTEXT:Angelica sinensis (Oliv.) Diels (Apiaceae) (syn. Angelica polymorpha Maxim var. sinensis Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect. OBJECTIVE:To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions. MATERIALS...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1844760
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities. OBJECTIVE:The aim of the study is the isolation of hesperidin from the peel of Citrus sinensis L. (Rutaceae), and the evaluation of its antioxidant capacity and cytotoxicit...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.509734
更新日期:2011-03-01 00:00:00
abstract:CONTEXT:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid (Aβ). Multiple Aβ-aggregated species have been identified, and neurotoxicity appears to be correlated with the amount of non-fibrillar oligomers. Potent inhibitors of Aβ oligomer formation or Aβ-indu...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.974062
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Schumanniophyton magnificum Harms (Rubiaceae) is used traditionally in Nigeria for the treatment of snake bites. Snake venom contains phospholipase A2 (PLA2) which plays a key role in causing inflammation and pain. OBJECTIVE:To assess the anti-inflammatory effect of the methanol extract of Schumanniophyton mag...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1839510
更新日期:2020-12-01 00:00:00
abstract::The in vitro. antifungal activity of the aqueous, ethanol, chloroform, petroleum ether, and residue extracts from 10 indigenous Bahraini plants used in folk medicine for the treatment of various diseases is reported. Extract efficacy was evaluated using the agar well diffusion assay against four filamentous fungi and ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880200590951766
更新日期:2005-01-01 00:00:00
abstract:CONTEXT:Neuropsychiatric disorders, like anxiety and depression, are global problems for clinical researchers in neurology. Recently, some authors have shown neuroprotective and anti-inflammatory effects of Scrophularia striata Boiss (Scrophulariaceae) extract in rodents. OBJECTIVE:The purpose of the current study was...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.749924
更新日期:2013-05-01 00:00:00
abstract::Eugenia jambolana Lam. (Myrtaceae) is widely used in folk medicine as an antidiabetic, but there is a lack of information about its toxicity, especially for the stem bark. The present study evaluated acute oral and repeated-dose toxicity of the stem bark aqueous extract of Eugenia jambolana (EJ) in albino mice and Wis...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903300204
更新日期:2010-08-01 00:00:00
abstract::Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903150427
更新日期:2010-04-01 00:00:00
abstract::Abstract Context: Diabetes mellitus (DM) type 2 is a chronic disease characterized by hyperglycemia and insulin resistance. Oxidative stress participates in development and progression of DM, in which changes of superoxide dismutase (SOD) and catalase (CAT) were noted in DM mice. Berberine has been widely used as an a...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.839714
更新日期:2013-11-05 00:00:00
abstract:CONTEXT:The nephron-protective efficacy of Abelmoschus manihot (Linn.) Medicus (Malvaceae) has been proved by randomized controlled clinical trial. OBJECTIVE:Flavonoids are main active components of A. manihot, which can be transformed into glucuronide/sulfate conjugates in vivo. Exploring the pharmacokinetic profile ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1068337
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Termitomyces clypeatus (Lyophyllaceae) is a filamentous edible mushroom, having ethnomedicinal uses. However, information about the antioxidant, anticancer and antitumour properties of this mushroom remains to be elucidated. OBJECTIVE:The study examines the in vitro antioxidant, anticancer and in vivo antitumo...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1168854
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. OBJECTIVE:This paper reviews the chemical compounds, biological activities and the ethn...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.1080/13880209.2017.1397178
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. OBJECTIVE:This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. MATERIALS AND METHODS:The pharmacokinetics of orally administered anastrozole (...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2018.1501584
更新日期:2018-12-01 00:00:00
abstract:CONTEXT:Ethnobotanical claims of medicinal plants used in northern Maputaland are limited. Objectives To establish scientific validity for a selection of the plants used in Maputaland to treat skin diseases. MATERIALS AND METHODS:Aqueous and dichloromethane-methanol extracts were prepared from 37 plant species which w...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1158287
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:Liposomes are increasingly employed to deliver chemotherapeutic agents, antisense oligonucleotides, and genes to various therapeutic targets. OBJECTIVE:The present investigation evaluates the ability of fusogenic pH-sensitive liposomes of rapamycin in increasing its antiproliferative effect on human breast ade...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.871640
更新日期:2014-07-01 00:00:00
abstract::Context: Naringenin and tofacitinib are often used together for treatment of rheumatoid arthritis in Chinese clinics.Objective: This experiment investigates the effect of naringenin on the pharmacokinetics of tofacitinib in rats.Materials and methods: Twelve Sprague-Dawley rats were randomly divided into two groups (e...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1738504
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Granulocyte colony stimulating factor (G-CSF) has been commonly used to treat neutropenia caused by chemotherapy, radiotherapy, and organ transplants. Improved in vitro efficacy of G-CSF has already been observed by conjugating it to polyethylene glycol (PEG). OBJECTIVE:The in vivo bioassay using tetrazolium d...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.943248
更新日期:2015-06-01 00:00:00
abstract:CONTEXT:Tagetes patula L. is one of the French marigold group of the Asteraceae family. It is recognized in folklore for its medicinal and pesticidal properties. OBJECTIVE:In search of more effective, but non-toxic compounds with antioxidative potential led to the bioassay guided isolation studies on the extracts of T...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.523006
更新日期:2011-05-01 00:00:00
abstract::The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903241853
更新日期:2010-06-01 00:00:00
abstract:CONTEXT:Safranal (SAF) is verified to have potential effects in promoting nerve growth. OBJECTIVES:This study verifies the role of SAF in promoting dopaminergic neurons growth in vitro and in vivo. MATERIAL AND METHODS:Rat neural stem cells (NSC) were treated with 1, 20, or 100 ng/mL of SAF, and the expression levels...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2018.1501705
更新日期:2018-12-01 00:00:00
abstract::2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda ellipt...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1076/1388-0209(200009)3841-AFT298
更新日期:2000-01-01 00:00:00
abstract:CONTEXT:Prunella vulgaris L. (Labiatae) is a perennial plant common in China and Europe and is rich in rosmarinic acid (RA), ursolic acid (UA), and oleanolic acid (OA). The dried spica of P. vulgaris has been used as traditional medicine in China for over a hundred years. To our best knowledge, no study has been conduc...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.658477
更新日期:2012-09-01 00:00:00
abstract:CONTEXT:Linum usitatissimum L. (Linaceae), commonly known as flaxseed, is a good source of dietary fiber and lignans. Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from flaxseed. OBJECTIVES:To isolate secoisolariciresinol diglucosi...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.877492
更新日期:2014-09-01 00:00:00
abstract::Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1125932
更新日期:2016-09-01 00:00:00