Flavonoid rich fraction of Punica granatum improves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals.

abstract：CONTEXT:Silymarin, a flavonolignan from Silybum marianum (L.) Gaertn. (Asteraceae), has been reported to have antioxidant and anti-inflammatory properties. Therefore, it may be worthwhile to study the effect of silymarin on wound healing. OBJECTIVE:To evaluate the effect of silymarin on human fibroblast cells in an in...

journal_title：Pharmaceutical biology

authors： Sharifi R,Pasalar P,Kamalinejad M,Dehpour AR,Tavangar SM,Paknejad M,Mehrabani Natanzi M,Nourbakhsh M,Ahmadi Ashtiani HR,Akbari M,Rastegar H

更新日期：2013-03-01 00:00:00

abstract：:A model for a database system that provides a standardized environment for submission, storage, and retrieval of ethnomedicinal data was developed. The model is based on object oriented database technology, and is suitable for not only storing data, digital images, sound and video, but also for modeling domain knowled...

journal_title：Pharmaceutical biology

authors： Thomas MB,Lin N,Beck HH

更新日期：2001-01-01 00:00:00

abstract：CONTEXT:The application of bleomycin is limited due to its side effects including lung toxicity. Silymarin is a flavonoid complex isolated from milk thistle [Silybum marianum L. (Asteraceae)] which has been identified as an antioxidant and anti-inflammatory compound. OBJECTIVE:This study evaluates the effect of silyma...

journal_title：Pharmaceutical biology

authors： Razavi-Azarkhiavi K,Ali-Omrani M,Solgi R,Bagheri P,Haji-Noormohammadi M,Amani N,Sepand MR

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:To date, there are no reports to validate the Indian traditional and folklore claims of Artemisia maderaspatana L. (syn. Grangea maderaspatana L.) (Asteraceae) for the treatment of Alzheimer's disease. OBJECTIVE:The present study characterizes the volatile components (non-polar compounds) of A. maderaspatana a...

journal_title：Pharmaceutical biology

authors： Jyotshna,Srivastava N,Singh B,Chanda D,Shanker K

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:The possibility of combining unripe plantain [Musa paradisiacae Linn (Plantaginaceae)] and cocoyam [Colocassia esculenta Linn (Araceae)] in the management of diabetes has not been investigated. OBJECTIVE:The objective of this study is to evaluate the antihyperglycemic and antihyperlipidemic actions of unripe p...

journal_title：Pharmaceutical biology

authors： Eleazu CO,Eleazu KC,Iroaganachi MA

更新日期：2016-01-01 00:00:00

abstract：:Context Diabetes is a global health challenge. Although large prospective clinical trials have shown that intensive control of blood glucose or blood pressure reduces the risk for development and progression of vascular complications in diabetes, a substantial number of diabetic patients still experience renal failure...

journal_title：Pharmaceutical biology

authors： Yamagishi S,Matsui T

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:The roots of Phytolacca americana L. (Phytolaccaceae) may be toxic. Despite heated controversy over the toxic compounds of P. americana, especially esculentosides, relevant studies remain scarce. OBJECTIVE:The objective of this study is to screen the toxic fractions and compounds of P. americana, to determine ...

journal_title：Pharmaceutical biology

authors： Yu H,Gong L,Wang X,Wu H,Zhao T,Wang K,Cui X,Chen L

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits. OBJECTIVE:The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. MATERIALS AND ...

journal_title：Pharmaceutical biology

authors： Amran AZ,Jantan I,Dianita R,Buang F

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:2,7-Dihydroxy-3-methylanthraquinone (DDMN) is reported to have a remarkable anticancer activity against gastric cancer SGC-7901 cells. OBJECTIVE:The objective of this study is to study the anticancer effect and mechanism of DDMN on SGC-7901 cells. MATERIALS AND METHODS:The MTT assay was used to determine the ...

journal_title：Pharmaceutical biology

authors： Zhu H,Zheng Z,Zhang J,Liu X,Liu Y,Yang W,Liu Y,Zhang T,Zhao Y,Liu Y,Su X,Gu X

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory ef...

journal_title：Pharmaceutical biology

authors： Si-Si W,Liao L,Ling Z,Yun-Xia Y

更新日期：2011-08-01 00:00:00

abstract：:Context The underground edible tuber of Dioscorea alata L. (Dioscoreaceae) is a functional food with high nutritive value and therapeutic potential. The tuber is known to possess anti-inflammatory properties in traditional medicine. Objective The present study explores the anti-inflammatory activity and standardisatio...

journal_title：Pharmaceutical biology

authors： Dey P,Roy Chowdhuri S,Sarkar MP,Chaudhuri TK

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Cardioprotective effects of various plants are generally attributed to their antioxidant activity. The whole fruit extract of pomegranate (WFEP), Punica granatum L. (Punicaceae), has a potent antioxidant activity. OBJECTIVE:To investigate cardioprotective effect of WFEP against doxorubicin (Dox)-induced cardio...

journal_title：Pharmaceutical biology

authors： Hassanpour Fard M,Ghule AE,Bodhankar SL,Dikshit M

更新日期：2011-04-01 00:00:00

abstract：CONTEXT:There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects. OBJECTIVE:To extract Bocfal EO, to identify and quantify its ...

journal_title：Pharmaceutical biology

authors： Morales-López J,Centeno-Álvarez M,Nieto-Camacho A,López MG,Pérez-Hernández E,Pérez-Hernández N,Fernández-Martínez E

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Many plant extracts and compounds are being investigated for their cytotoxicity and hence their medicinal or therapeutic properties. Reports of toxicity studies with limonoid analogs have been sparse and have involved mainly crude extracts. In this study, individual natural limonoids have been isolated and thei...

journal_title：Pharmaceutical biology

authors： Fowles RG,Mootoo BS,Ramsewak RS,Khan A

更新日期：2012-02-01 00:00:00

abstract：:The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...

journal_title：Pharmaceutical biology

authors： Jimenez-Coello M,Acosta-Viana KY,Guzman-Marin E,Perez Gonzalez C,Salud Perez Gutierrez M

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. OBJECTIVE:The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. MATERIALS AND METHOD...

journal_title：Pharmaceutical biology

authors： Seif el-Din SH,El-Lakkany NM,Mohamed MA,Hamed MM,Sterner O,Botros SS

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:Amphibian skins have wide variety of biologically active compounds associated with the natural defenses of these animals. OBJECTIVES:To study the in vitro anticancer activity of methanol extracts of the skin of Rhinella jimi Stevaux (Anura: Bufonidae). MATERIAL AND METHODS:The extract was obtained by cold met...

journal_title：Pharmaceutical biology

authors： Brito SV,Sales DL,Costa JG,Rodrigues FF,Ferreira FS,Angélico EC,Carvalho JE,Almeida WO,Anjos LA,Coutinho HD

更新日期：2012-08-01 00:00:00

abstract：CONTEXT:1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. OBJECTIVE:To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 ...

journal_title：Pharmaceutical biology

authors： Sun J,Jiang T,Xu W,Feng Z,Quan X,Leng P,Sun W,Zhao J,Jing F,Li J

更新日期：2019-12-01 00:00:00

abstract：CONTENT:Rosa damascena Mill. (Rosaceae) is an important ornamental and medicinal plant and a source of fragrance. Its hydrosol is known in Iran as golab (rose water) and has applications in religious ceremonies, food, and pharmaceuticals. Hydrosol is traditionally and industrially produced by distillation. The increase...

journal_title：Pharmaceutical biology

authors： Moein M,Zarshenas MM,Delnavaz S

更新日期：2014-10-01 00:00:00

abstract：CONTEXT:Viola tianshanica Maxim. (Violaceae) is a perennial herb distributed in Central Asia, especially in the Xinjiang Uygur Autonomous Region (XUAR) of China. Preliminary study showed that the ethanol extract of the herb exhibited the anti-complement activity against the classical pathway, but the active components ...

journal_title：Pharmaceutical biology

authors： Qin Y,Wen Q,Cao J,Yin C,Chen D,Cheng Z

更新日期：2016-07-01 00:00:00

abstract：CONTEXT:Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. OBJECTIVE:This study evaluated the effects of methanol extracts ...

journal_title：Pharmaceutical biology

authors： Hocayen Pde A,Grassiolli S,Leite NC,Pochapski MT,Pereira RA,da Silva LA,Snack AL,Michel RG,Kagimura FY,da Cunha MA,Malfatti CR

更新日期：2016-07-01 00:00:00

abstract：CONTEXT:Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen spec...

journal_title：Pharmaceutical biology

authors： Kanikowska D,Kanikowska A,Rutkowski R,Włochal M,Orzechowska Z,Juchacz A,Zawada A,Grzymisławski M,Roszak M,Sato M,Bręborowicz A,Witowski J

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...

journal_title：Pharmaceutical biology

authors： Lee HM,Park MY,Kim J,Shin JH,Park KS,Kwon O

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Cyclophosphamide (CP) causes lung injury in rats through its ability to generate free radicals with subsequent epithelial and endothelial cell damage. OBJECTIVE:This study was conducted to assess whether allicin can ameliorate CP-induced early lung injury in rats. MATERIALS AND METHODS:Male Sprague Dawely rat...

journal_title：Pharmaceutical biology

authors： Ashry NA,Gameil NM,Suddek GM

更新日期：2013-06-01 00:00:00

abstract：:Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.Objective: To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...

journal_title：Pharmaceutical biology

authors： Dai X,Yang D,Bao J,Zhang Q,Ding J,Liu M,Ding M,Liu M,Liang J,Jia X

更新日期：2020-12-01 00:00:00

abstract：:Context Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown that root extracts are rich in polyphenolic compounds with antibacterial, antiviral and immunomodulatory activities. Little is known regarding the anticancer properties of P...

journal_title：Pharmaceutical biology

authors： Pereira A,Bester M,Soundy P,Apostolides Z

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Chrysanthemum boreale Makino (Compositae) (CBM) is a traditional medicine that has been used for the prevention or treatment of various disorders; it has various properties including antioxidation, anti-inflammation, and antitumor. OBJECTIVE:The present study was designed to explore the in vitro effect of CBM ...

journal_title：Pharmaceutical biology

authors： Kim DY,Won KJ,Yoon MS,Yu HJ,Park JH,Kim B,Lee HM

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. OBJECTIVE:This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)-...

journal_title：Pharmaceutical biology

authors： Paduch R,Trytek M,Król SK,Kud J,Frant M,Kandefer-Szerszeń M,Fiedurek J

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Curcumol has recently attracted special attention due to its potential activities in many chronic disorders. Moreover, the traditional role of turmeric [Curcuma longa L. (Zingiberaceae)] in suppression of hyperglycemia is of great interest. OBJECTIVES:The present work explores the potential acute and subchroni...

journal_title：Pharmaceutical biology

authors： Raafat KM,Omar AG

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Tournefortia sarmentosa Lam. (Boraginaceae), a Chinese herbal medicine, is commonly used as a detoxicant or anti-inflammatory agent. OBJECTIVE:As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T. sarmentosa on APAP-induced hepatotoxicity in vivo and i...

journal_title：Pharmaceutical biology

authors： Teng CY,Lai YL,Huang HI,Hsu WH,Yang CC,Kuo WH

更新日期：2012-03-01 00:00:00