Abstract:
CONTEXT:Magnesium lithospermate B (MLB), an active polyphenol acid of Danshen [Radix Salviae miltiorrhizae (Labiatae)], showed renoprotective, neuroprotective and myocardial salvage effects. Previous studies demonstrated that MLB could effectively suppress the production of cytokines and their associated signaling pathways in activated human T cells. OBJECTIVE:The purpose of this study was to examine the beneficial effects of MLB on myocardial ischemia/reperfusion (MI/R) injury and to explore its potential mechanisms related to anti-inflammation. MATERIALS AND METHODS:Sprague-Dawley rats were grouped as sham group, model group and MLB-treated (15, 30 and 60 mg/kg) groups. Animals were subjected to MI/R injury by the occlusion of left anterior descending artery for 30 min followed by reperfusion for 3 h. At the end of reperfusion, blood samples were collected to determine the serum levels of cardiac troponin (cTnI), creatine kinase-MB (CK-MB), tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6). Hearts were harvested to assess infarct size, histopathological changes and the activity of myeloperoxidase (MPO). The expression of phosphor-IkB-α and phosphor-nuclear factor kappa B (NF-κB) were assayed by western blot. RESULTS:MLB administration significantly (p < 0.05) reduced: (1) ST-segment elevation (0.23 mv), (2) the infarct size (22.5%), (3) histological scores of myocardial injury (1.67 score), (4) myocardial injury marker enzymes: cTnI (5.64 ng/ml) and CK-MB (49.57 ng/ml) levels, (5) pro-inflammatory cytokines: TNF-α (97.36 pg/ml), IL-1β (93.35 pg/ml) and IL-6 (96.84 pg/ml) levels, (6) MPO activity (1.82 U/mg), (7) phosphor-NF-κB (0.87) and phosphor-IkB-α (0.96) expression. DISCUSSION AND CONCLUSION:Our study provided evidence that MLB ameliorated the inflammatory process associated with MI/R injury via NF-κB inactivation.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Quan W,Wei G,Zhou D,Zhu Y,Guo C,Wang Y,Weng Y,Xi M,Wen Adoi
10.3109/13880209.2013.791324subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1355-62issue
11eissn
1388-0209issn
1744-5116journal_volume
51pub_type
杂志文章abstract:CONTEXT:Sheng-Mai-San (SMS) has been used for the treatment of cardiovascular disease for many years in China. OBJECTIVES:This study investigated the protective effects and active ingredients of SMS on myocardial injury (MI) in mice. MATERIALS AND METHODS:SMS and n-butanol extraction of SMS (SMS-Bu) were prepared and...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.784920
更新日期:2013-10-01 00:00:00
abstract:CONTEXT:Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen spec...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,随机对照试验
doi:10.1080/13880209.2019.1569696
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abstract::Clitoria ternatea , commonly known as Shankpushpi, is widely used in the traditional Indian system of medicine as a brain tonic and is believed to promote memory and intelligence. We examined the effectiveness of alcoholic extracts of aerial and root parts of C. ternatea at 300 and 500 mg/kg doses orally in rats in at...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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abstract::Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant...
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abstract:CONTEXT:Ferula cupularis (Boiss.) Spalik et S. R. Downie (Apiaceae) is a common plant in Iran that grows in the foothills of Dena Mountain. In traditional folk medicine, this plant has different applications, but there are no studies proving their uses. OBJECTIVE:This study is the first attempt to investigate the chem...
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doi:10.3109/13880209.2014.924149
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1133658
更新日期:2016-09-01 00:00:00
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更新日期:2000-01-01 00:00:00
abstract::Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Material...
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/13880209.2014.889176
更新日期:2014-10-01 00:00:00
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2014.957782
更新日期:2015-07-01 00:00:00
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journal_title:Pharmaceutical biology
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更新日期:2016-09-01 00:00:00
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更新日期:2013-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:2014-02-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2012-08-01 00:00:00
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更新日期:2019-12-01 00:00:00
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更新日期:2015-02-01 00:00:00
abstract::Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...
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更新日期:2015-01-01 00:00:00
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00