Abstract:
:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific EphA7 enhancer resides on the 457D20 EphA7 BAC clone and is localized to a 35 kb genomic region in between +345.7 kb to +379.8 kb downstream of the EphA7 transcription start site. Identification of the EphA7 BAC clone containing a long-range dorsal midline enhancer may constitute a useful tool for investigating the biological functions of EphA7 in vivo.
journal_name
BMB Repjournal_title
BMB reportsauthors
Kim Y,Park Sdoi
10.5483/BMBRep.2011.44.2.113subject
Has Abstractpub_date
2011-02-01 00:00:00pages
113-7issue
2eissn
1976-6696issn
1976-670Xjournal_volume
44pub_type
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