Abstract:
:Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link between SCs, longevity, and ARDs. Therefore, senotherapeutics, medicines targeting SCs, might be an emerging strategy for the extension of health span, and prevention or treatment of ARDs. Senotherapeutics are classified as senolytics which kills SCs selectively; senomorphics which modulate functions and morphology of SCs to those of young cells, or delays the progression of young cells to SCs in tissues; and immune-system mediators of the clearance of SCs. Some senolytics and senomorphics have been proven to markedly prevent or treat ARDs in animal models. This review will present the current status of the development of senotherapeutics, in relation to aging itself and ARDs. Finally, future directions and opportunities for senotherapeutics use will discussed. This knowledge will provide information that can be used to develop novel senotherapeutics for health span and ARDs. [BMB Reports 2019; 52(1): 47-55].
journal_name
BMB Repjournal_title
BMB reportsauthors
Kim EC,Kim JRsubject
Has Abstractpub_date
2019-01-01 00:00:00pages
47-55issue
1eissn
1976-6696issn
1976-670Xpii
4446journal_volume
52pub_type
杂志文章,评审相关文献
BMB Reports文献大全abstract::In order to clarify the impact of Ca-binding sites (Ca1 and 2) on the conformational stability of neutral proteases (NPs), we have analyzed the thermal, pH and organic solvent stability of a NP variant, V189P/A195E/G203D/A268E (Q-mutant), from Salinovibrio proteolyticus. This mutant has shown to bind calcium more tigh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.10.665
更新日期:2011-10-01 00:00:00
abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.12.794
更新日期:2009-12-31 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.5.271
更新日期:2009-05-31 00:00:00
abstract::The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.11.157
更新日期:2017-11-01 00:00:00
abstract::The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BA...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.4.257
更新日期:2010-04-01 00:00:00
abstract::Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2016.49.7.011
更新日期:2016-07-01 00:00:00
abstract::GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-04-01 00:00:00
abstract::Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-11-01 00:00:00
abstract::Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2013.46.12.271
更新日期:2013-12-01 00:00:00
abstract::The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. The full-length cDNA was 2204 base pair (bp) and contained a single 1968 bp ORF that encoded a polypeptide of 656 amino acids with a predicted molecular mass of 71.28 kDa. Phylogenetic analysis base...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.5.388
更新日期:2008-05-31 00:00:00
abstract::Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been stea...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.3.248
更新日期:2008-03-31 00:00:00
abstract::Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.11.175
更新日期:2017-11-01 00:00:00
abstract::Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.3.142
更新日期:2009-03-31 00:00:00
abstract::The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.5.201
更新日期:2017-05-01 00:00:00
abstract::The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.11.764
更新日期:2009-11-30 00:00:00
abstract::Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.6.407
更新日期:2010-06-01 00:00:00
abstract::Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2016.49.4.044
更新日期:2016-04-01 00:00:00
abstract::The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.159
更新日期:2014-08-01 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.5.275
更新日期:2012-05-01 00:00:00
abstract::The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.012
更新日期:2018-03-01 00:00:00
abstract::Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract::Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.2.113
更新日期:2011-02-01 00:00:00
abstract::We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.6.331
更新日期:2009-06-30 00:00:00
abstract::Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2020-02-01 00:00:00
abstract::To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour an...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.4.193
更新日期:2013-04-01 00:00:00
abstract::PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.1.048
更新日期:2008-01-31 00:00:00