Senotherapeutics: emerging strategy for healthy aging and age-related disease.

abstract：:To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

journal_title：BMB reports

authors： Xue X,Liu A,Hua X

更新日期：2009-01-31 00:00:00

abstract：:Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

journal_title：BMB reports

authors： Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

更新日期：2009-05-31 00:00:00

abstract：:The bactenecin is an antibacterial peptide with an intramolecular disulfide bond. We recently found that homodimeric bactenecin exhibits more potent antibacterial activity than the monomeric form and retains its activity at physiological conditions. Here we assess the difference in the modes of antibiotic action of ho...

journal_title：BMB reports

authors： Lee JY,Yang ST,Kim HJ,Lee SK,Jung HH,Shin SY,Kim JI

更新日期：2009-09-30 00:00:00

abstract：:In this study, we cloned the ERF-B3 subfamily transcription factor gene BnaERF-B3-hy15 from Brassica napus L. Huyou15. This 600 bp gene encodes a 199 amino acid classic ethylene responsive factor (ERF), which shown no binding or very weak binding GCC box-binding activity by the yeast one-hybrid assay. We used gene shu...

journal_title：BMB reports

authors： Jin XF,Zhu B,Peng RH,Jiang HH,Chen JM,Zhuang J,Zhang J,Yao QH,Xiong AS

更新日期：2010-08-01 00:00:00

abstract：:The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...

journal_title：BMB reports

authors： Kim SO,Choi BT,Choi IW,Cheong J,Kim GY,Kwon TK,Kim ND,Choi YH

更新日期：2009-10-31 00:00:00

abstract：:Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

journal_title：BMB reports

authors： Kim SJ,Chun KH

更新日期：2020-04-01 00:00:00

abstract：:Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...

journal_title：BMB reports

authors： Tran ST,Le DT,Kim YC,Shin M,Choi JD

更新日期：2009-08-31 00:00:00

abstract：:Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on t...

journal_title：BMB reports

authors： Choe BI,Lee GH

更新日期：2017-12-01 00:00:00

abstract：:The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

journal_title：BMB reports

authors： Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

更新日期：2015-07-01 00:00:00

abstract：:The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

journal_title：BMB reports

authors： Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

更新日期：2017-05-01 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...

journal_title：BMB reports

authors： Shin HI,Chae KH,Cho TJ

更新日期：2013-10-01 00:00:00

abstract：:Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...

journal_title：BMB reports

authors： Kim HE,Cho H,Ishihara A,Kim B,Kim O

更新日期：2018-04-01 00:00:00

abstract：:We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

journal_title：BMB reports

authors： Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

更新日期：2017-12-01 00:00:00

abstract：:In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...

journal_title：BMB reports

authors： Kim JI,Choi DI,Kaang BK

更新日期：2018-08-01 00:00:00

abstract：:Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...

journal_title：BMB reports

authors： Kang IS,Suh J,Lee MN,Lee C,Jin J,Lee C,Yang YI,Jang Y,Oh GT

更新日期：2020-02-01 00:00:00

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00

abstract：:The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...

journal_title：BMB reports

authors： Seo J,Kim J

更新日期：2018-03-01 00:00:00

abstract：:Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...

journal_title：BMB reports

authors： Jang WG,Kim EJ,Koh JT

更新日期：2011-11-01 00:00:00

abstract：:Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...

journal_title：BMB reports

authors： Yu NK,Kaang BK

更新日期：2016-04-01 00:00:00

abstract：:The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...

journal_title：BMB reports

authors： Luo N,Li G,Li Y,Fan X,Wang Y,Ye X,Mo X,Zhou J,Yuan W,Tan M,Xie H,Ocorr K,Bodmer R,Deng Y,Wu X

更新日期：2010-05-01 00:00:00

abstract：:Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...

journal_title：BMB reports

authors： Liao ZQ,Ye M,Yu PG,Xiao C,Lin FY

更新日期：2016-07-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...

journal_title：BMB reports

authors： Lee B,Shin YJ,Lee SM,Son YH,Yang YR,Lee KP

更新日期：2020-05-01 00:00:00

abstract：:Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

journal_title：BMB reports

authors： Yoo S

更新日期：2010-06-01 00:00:00

abstract：:Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...

journal_title：BMB reports

authors： Shin EC

更新日期：2021-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in...

journal_title：BMB reports

authors： Jegal ME,Jung SY,Han YS,Kim YJ

更新日期：2019-05-01 00:00:00

abstract：:In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...

journal_title：BMB reports

authors： Shin J,Youn HD

更新日期：2016-10-01 00:00:00

abstract：:Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...

journal_title：BMB reports

authors： Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JY

更新日期：2009-07-31 00:00:00

abstract：:Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

journal_title：BMB reports

authors： Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

更新日期：2015-09-01 00:00:00

abstract：:Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...

journal_title：BMB reports

authors： Altintas O,Park S,Lee SJ

更新日期：2016-02-01 00:00:00