Senotherapeutics: emerging strategy for healthy aging and age-related disease.


:Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link between SCs, longevity, and ARDs. Therefore, senotherapeutics, medicines targeting SCs, might be an emerging strategy for the extension of health span, and prevention or treatment of ARDs. Senotherapeutics are classified as senolytics which kills SCs selectively; senomorphics which modulate functions and morphology of SCs to those of young cells, or delays the progression of young cells to SCs in tissues; and immune-system mediators of the clearance of SCs. Some senolytics and senomorphics have been proven to markedly prevent or treat ARDs in animal models. This review will present the current status of the development of senotherapeutics, in relation to aging itself and ARDs. Finally, future directions and opportunities for senotherapeutics use will discussed. This knowledge will provide information that can be used to develop novel senotherapeutics for health span and ARDs. [BMB Reports 2019; 52(1): 47-55].




BMB reports


Kim EC,Kim JR


Has Abstract


2019-01-01 00:00:00














  • Proline accumulation and transcriptional regulation of proline biosynthesis and degradation in Brassica napus.

    abstract::To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Xue X,Liu A,Hua X

    更新日期:2009-01-31 00:00:00

  • Characterization of full-length enriched expressed sequence tags of dehydration-treated white fibrous roots of sweetpotato.

    abstract::Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

    更新日期:2009-05-31 00:00:00

  • Different modes of antibiotic action of homodimeric and monomeric bactenecin, a cathelicidin-derived antibacterial peptide.

    abstract::The bactenecin is an antibacterial peptide with an intramolecular disulfide bond. We recently found that homodimeric bactenecin exhibits more potent antibacterial activity than the monomeric form and retains its activity at physiological conditions. Here we assess the difference in the modes of antibiotic action of ho...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee JY,Yang ST,Kim HJ,Lee SK,Jung HH,Shin SY,Kim JI

    更新日期:2009-09-30 00:00:00

  • Optimizing the binding activity of the AP2/ERF transcription factor with the GCC box element from Brassica napus by directed evolution.

    abstract::In this study, we cloned the ERF-B3 subfamily transcription factor gene BnaERF-B3-hy15 from Brassica napus L. Huyou15. This 600 bp gene encodes a 199 amino acid classic ethylene responsive factor (ERF), which shown no binding or very weak binding GCC box-binding activity by the yeast one-hybrid assay. We used gene shu...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Jin XF,Zhu B,Peng RH,Jiang HH,Chen JM,Zhuang J,Zhang J,Yao QH,Xiong AS

    更新日期:2010-08-01 00:00:00

  • Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells.

    abstract::The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim SO,Choi BT,Choi IW,Cheong J,Kim GY,Kwon TK,Kim ND,Choi YH

    更新日期:2009-10-31 00:00:00

  • Non-classical role of Galectin-3 in cancer progression: translocation to nucleus by carbohydrate-recognition independent manner.

    abstract::Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Kim SJ,Chun KH

    更新日期:2020-04-01 00:00:00

  • Cloning and characterization of phosphomannose isomerase from Sphingomonas chungbukensis DJ77.

    abstract::Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Tran ST,Le DT,Kim YC,Shin M,Choi JD

    更新日期:2009-08-31 00:00:00

  • Promoting and improving three Rs practice: the Korean guidelines.

    abstract::Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on t...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Choe BI,Lee GH

    更新日期:2017-12-01 00:00:00

  • PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model.

    abstract::The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

    更新日期:2015-07-01 00:00:00

  • Structural characterization of As-MIF and hJAB1 during the inhibition of cell-cycle regulation.

    abstract::The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

    更新日期:2017-05-01 00:00:00

  • Modification of Turnip yellow mosaic virus coat protein and its effect on virion assembly.

    abstract::Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Shin HI,Chae KH,Cho TJ

    更新日期:2013-10-01 00:00:00

  • Cell proliferation and migration mechanism of caffeoylserotonin and serotonin via serotonin 2B receptor in human keratinocyte HaCaT cells.

    abstract::Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim HE,Cho H,Ishihara A,Kim B,Kim O

    更新日期:2018-04-01 00:00:00

  • Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer.

    abstract::We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

    更新日期:2017-12-01 00:00:00

  • Strengthened connections between engrams encode specific memories.

    abstract::In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Kim JI,Choi DI,Kaang BK

    更新日期:2018-08-01 00:00:00

  • Characterization of human cardiac mesenchymal stromal cells and their extracellular vesicles comparing with human bone marrow derived mesenchymal stem cells.

    abstract::Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kang IS,Suh J,Lee MN,Lee C,Jin J,Lee C,Yang YI,Jang Y,Oh GT

    更新日期:2020-02-01 00:00:00

  • AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells.

    abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

    更新日期:2014-08-01 00:00:00

  • Regulation of Hippo signaling by actin remodeling.

    abstract::The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Seo J,Kim J

    更新日期:2018-03-01 00:00:00

  • Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells.

    abstract::Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Jang WG,Kim EJ,Koh JT

    更新日期:2011-11-01 00:00:00

  • Gene repressive mechanisms in the mouse brain involved in memory formation.

    abstract::Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Yu NK,Kaang BK

    更新日期:2016-04-01 00:00:00

  • SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

    abstract::The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Luo N,Li G,Li Y,Fan X,Wang Y,Ye X,Mo X,Zhou J,Yuan W,Tan M,Xie H,Ocorr K,Bodmer R,Deng Y,Wu X

    更新日期:2010-05-01 00:00:00

  • Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis.

    abstract::Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Liao ZQ,Ye M,Yu PG,Xiao C,Lin FY

    更新日期:2016-07-01 00:00:00

  • Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines.

    abstract::Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Iqbal MA,Hong K,Kim JH,Choi Y

    更新日期:2019-11-01 00:00:00

  • miR-3074-3p promotes myoblast differentiation by targeting Cav1.

    abstract::Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Lee B,Shin YJ,Lee SM,Son YH,Yang YR,Lee KP

    更新日期:2020-05-01 00:00:00

  • Kinetic analysis of Drosophila Vnd protein containing homeodomain with its target sequence.

    abstract::Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Yoo S

    更新日期:2010-06-01 00:00:00

  • Cancer immunotherapy: special issue of BMB Reports in 2021.

    abstract::Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Shin EC

    更新日期:2021-01-01 00:00:00

  • C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells.

    abstract::Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Jegal ME,Jung SY,Han YS,Kim YJ

    更新日期:2019-05-01 00:00:00

  • Oct4 resetting by Aurkb-PP1 cell cycle axis determines the identity of mouse embryonic stem cells.

    abstract::In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Shin J,Youn HD

    更新日期:2016-10-01 00:00:00

  • Static tensional forces increase osteogenic gene expression in three-dimensional periodontal ligament cell culture.

    abstract::Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JY

    更新日期:2009-07-31 00:00:00

  • Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1.

    abstract::Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

    更新日期:2015-09-01 00:00:00

  • The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster.

    abstract::Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Altintas O,Park S,Lee SJ

    更新日期:2016-02-01 00:00:00