解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-07 00:00:00
abstract::Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-01 00:00:00
abstract::In the last decade, we have witnessed an unprecedented clinical success in cancer immunotherapies targeting the programmed cell-death ligand 1 (PD-L1) and programmed cell-death 1 (PD-1) pathway. Besides the fact that PD-L1 plays a key role in immune regulation in tumor microenvironment, recently a plethora of reports ...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-01 00:00:00
abstract::The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-12-01 00:00:00
abstract::Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-11-01 00:00:00
abstract::Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-08-26 00:00:00
abstract::Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of ...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-06-01 00:00:00
abstract::Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-06-01 00:00:00
abstract::Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-05-01 00:00:00
abstract::Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been stea...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2020-02-01 00:00:00
abstract::Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-12-01 00:00:00
abstract::Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-11-01 00:00:00
abstract::Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-10-01 00:00:00
abstract::Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. ...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-09-01 00:00:00
abstract::Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was a...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-09-01 00:00:00
abstract::Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-08-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipi...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-05-01 00:00:00
abstract::GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-04-01 00:00:00
abstract::Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
abstract::Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related path...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-01-01 00:00:00
abstract::Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...
journal_title:BMB reports
pub_type: 社论
doi:
更新日期:2019-01-01 00:00:00
abstract::RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chroma...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2018-12-01 00:00:00
abstract::DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2018-12-01 00:00:00
abstract::Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract::Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in or...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract::In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2018-08-01 00:00:00
abstract::Skeletal muscle contracts or relaxes to maintain the body position and locomotion. For the contraction and relaxation of skeletal muscle, Ca2+ in the cytosol of skeletal muscle fibers acts as a switch to turn on and off a series of contractile proteins. The cytosolic Ca2+ level in skeletal muscle fibers is governed ma...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.8.128
更新日期:2018-08-01 00:00:00
abstract::Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.6.025
更新日期:2018-06-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2018.51.4.005
更新日期:2018-04-01 00:00:00
abstract::Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2018.51.4.209
更新日期:2018-04-01 00:00:00
abstract::The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.012
更新日期:2018-03-01 00:00:00
abstract::Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.027
更新日期:2018-03-01 00:00:00
abstract::We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.12.177
更新日期:2017-12-01 00:00:00
abstract::Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on t...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.12.225
更新日期:2017-12-01 00:00:00
abstract::The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.11.157
更新日期:2017-11-01 00:00:00