Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production.

Abstract:

:The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.

journal_name

BMB Rep

journal_title

BMB reports

authors

Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

doi

10.5483/bmbrep.2009.42.12.794

subject

Has Abstract

pub_date

2009-12-31 00:00:00

pages

794-9

issue

12

eissn

1976-6696

issn

1976-670X

journal_volume

42

pub_type

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