Abstract:
:Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many studies have reported age prediction models based on DNA methylation from various tissues and body fluids. Those models seem to be very promising because of their high prediction accuracies. In this review, the changes of age-associated DNA methylation and the age prediction models for various tissues and body fluids were examined, and then the applicability of the DNA methylation-based age prediction method to the forensic investigations was discussed. This will improve the understandings about DNA methylation markers and their potential to be used as biomarkers in the forensic field, as well as the clinical field. [BMB Reports 2017; 50(11): 546-553].
journal_name
BMB Repjournal_title
BMB reportsauthors
Jung SE,Shin KJ,Lee HYdoi
10.5483/bmbrep.2017.50.11.175subject
Has Abstractpub_date
2017-11-01 00:00:00pages
546-553issue
11eissn
1976-6696issn
1976-670Xpii
3978journal_volume
50pub_type
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