EvoSNP-DB: A database of genetic diversity in East Asian populations.

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...

journal_title：BMB reports

authors： Lee E,Jeong KW,Lee J,Shin A,Kim JK,Lee J,Lee DG,Kim Y

更新日期：2013-05-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...

journal_title：BMB reports

authors： Choi YK,Tarazi FI

更新日期：2010-09-01 00:00:00

abstract：:The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...

journal_title：BMB reports

authors： Shi HH,Liu HE,Luo XJ

更新日期：2020-12-01 00:00:00

abstract：:Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

journal_title：BMB reports

authors： Yoo S

更新日期：2010-06-01 00:00:00

abstract：:PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...

journal_title：BMB reports

authors： Kim DU,Yoo JH,Lee YJ,Kim KS,Cho HS

更新日期：2008-01-31 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...

journal_title：BMB reports

authors： Kim JH

更新日期：2019-04-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...

journal_title：BMB reports

authors： Hwang HS,Lee MH,Choi MH,Kim HA

更新日期：2019-06-01 00:00:00

abstract：:The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...

journal_title：BMB reports

authors： Xu H,Duan J,Ning D,Li J,Liu R,Yang R,Jiang JX,Shang P

更新日期：2014-12-01 00:00:00

abstract：:Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen-activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor ...

journal_title：BMB reports

authors： You Y,Li W,Gong Y,Yin B,Qiang B,Yuan J,Peng X

更新日期：2010-07-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for...

journal_title：BMB reports

authors： Lee SJ,Park JW

更新日期：2014-04-01 00:00:00

abstract：:Cell proliferation is a delicately regulated process that couples growth signals and metabolic demands to produce daughter cells. Interestingly, the proliferation of tumor cells immensely depends on glycolysis, the Warburg effect, to ensure a sufficient amount of metabolic flux and bioenergetics for macromolecule synt...

journal_title：BMB reports

authors： Kee HJ,Cheong JH

更新日期：2014-03-01 00:00:00

abstract：:We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...

journal_title：BMB reports

authors： Yang Y,Chen L,Pan HZ,Kou Y,Xu CM

更新日期：2009-06-30 00:00:00

abstract：:Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

journal_title：BMB reports

authors： Lee EW,Seo J,Jeong M,Lee S,Song J

更新日期：2012-09-01 00:00:00

abstract：:The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...

journal_title：BMB reports

authors： Kim SO,Choi BT,Choi IW,Cheong J,Kim GY,Kwon TK,Kim ND,Choi YH

更新日期：2009-10-31 00:00:00

abstract：:In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB ...

journal_title：BMB reports

authors： Deng Y,Liu B,Fan X,Wang Y,Tang M,Mo X,Li Y,Ying Z,Wan Y,Luo N,Zhou J,Wu X,Yuan W

更新日期：2010-03-01 00:00:00

abstract：:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...

journal_title：BMB reports

authors： Kwon OS,Han MJ,Cha HJ

更新日期：2017-09-01 00:00:00

abstract：:Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...

journal_title：BMB reports

authors： Yeo H,Lee JY,Kim J,Ahn SS,Jeong JY,Choi JH,Lee YH,Shin SY

更新日期：2020-06-01 00:00:00

abstract：:Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in or...

journal_title：BMB reports

authors： Chae J,Park WS,Kim MJ,Jang SS,Hong D,Ryu J,Ryu CH,Kim JH,Choi MK,Cho KH,Moon SH,Yun T,Kim JI,Jung YS

更新日期：2018-11-01 00:00:00

abstract：:Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...

journal_title：BMB reports

authors： Park SW,Jun YW,Choi HE,Lee JA,Jang DJ

更新日期：2019-10-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegeneration. Oxidative modification of neurofilament proteins has been implicated in the pathogenesis of neurodegenerative disorders. In this study, oxidative m...

journal_title：BMB reports

authors： Kang JH

更新日期：2012-02-01 00:00:00

abstract：:FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in FaO rat hepatoma cells. TGF-beta1 caused a time-dependent activation of ...

journal_title：BMB reports

authors： Kim BC

更新日期：2008-10-31 00:00:00

abstract：:Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...

journal_title：BMB reports

authors： Lee D,Lee JW

更新日期：2015-03-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin...

journal_title：BMB reports

authors： Cui ZG,Hong NY,Guan J,Kang HK,Lee DH,Lee YK,Park DB

更新日期：2011-03-01 00:00:00

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00

abstract：:Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

journal_title：BMB reports

authors： Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

更新日期：2009-05-31 00:00:00

abstract：:Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...

journal_title：BMB reports

authors： Kim JK,Cho IJ,Kim EO,Lee DG,Jung DH,Ki SH,Ku SK,Kim SC

更新日期：2020-08-26 00:00:00