KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

abstract：:Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...

journal_title：BMB reports

authors： Chen X,Sun Y,Cai R,Wang G,Shu X,Pang W

更新日期：2018-06-01 00:00:00

abstract：:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...

journal_title：BMB reports

authors： Kim Y,Park S

更新日期：2011-02-01 00:00:00

abstract：:Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...

journal_title：BMB reports

authors： Liu Y,Zhang C,Shen X,Zhang X,Cichello S,Guan H,Liu P

更新日期：2013-12-01 00:00:00

abstract：:Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...

journal_title：BMB reports

authors： Im CN,Seo JS

更新日期：2014-05-01 00:00:00

abstract：:During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins...

journal_title：BMB reports

authors： Evans I,Kim MY

更新日期：2009-04-30 00:00:00

abstract：:Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...

journal_title：BMB reports

authors： Lee E,Jeong KW,Lee J,Shin A,Kim JK,Lee J,Lee DG,Kim Y

更新日期：2013-05-01 00:00:00

abstract：:Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...

journal_title：BMB reports

authors： Lee D,Lee JW

更新日期：2015-03-01 00:00:00

abstract：:Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...

journal_title：BMB reports

authors： Kim HE,Cho H,Ishihara A,Kim B,Kim O

更新日期：2018-04-01 00:00:00

abstract：:The AML1 gene is an essential transcription factor regulating the differentiation of hematopoietic stem cells into mature blood cells. Though at least 12 different alternatively spliced AML1 mRNAs are generated, three splice variants (AML1a, AML1b and AML1c) have been characterized. Here, using the reverse transcripti...

journal_title：BMB reports

authors： Xu AN,Chen XH,Tan YH,Qi XL,Xu ZF,Zhang LL,Ren FG,Bian SC,Chen Y,Wang HW

更新日期：2013-03-01 00:00:00

abstract：:Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...

journal_title：BMB reports

authors： Yeo H,Lee JY,Kim J,Ahn SS,Jeong JY,Choi JH,Lee YH,Shin SY

更新日期：2020-06-01 00:00:00

abstract：:Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...

journal_title：BMB reports

authors： Park SW,Jun YW,Choi HE,Lee JA,Jang DJ

更新日期：2019-10-01 00:00:00

abstract：:Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...

journal_title：BMB reports

authors： Liao ZQ,Ye M,Yu PG,Xiao C,Lin FY

更新日期：2016-07-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...

journal_title：BMB reports

authors： Shi HH,Liu HE,Luo XJ

更新日期：2020-12-01 00:00:00

abstract：:Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...

journal_title：BMB reports

authors： Park SH,Lee AR,Choi K,Joung S,Yoon JB,Kim S

更新日期：2019-12-01 00:00:00

abstract：:Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...

journal_title：BMB reports

authors： Jang HJ,Bak Y,Pham TH,Kwon SB,Kim BY,Hong J,Yoon DY

更新日期：2018-11-01 00:00:00

abstract：:The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155...

journal_title：BMB reports

authors： Lee EW,Oh W,Song HP,Kim WK

更新日期：2017-07-01 00:00:00

abstract：:Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

journal_title：BMB reports

authors： Kim SJ,Chun KH

更新日期：2020-04-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased ...

journal_title：BMB reports

authors： Moon Y,Park B,Park H

更新日期：2016-03-01 00:00:00

abstract：:The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...

journal_title：BMB reports

authors： Park YJ,Lee JM,Shin SY,Kim YH

更新日期：2014-12-01 00:00:00

abstract：:Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of ...

journal_title：BMB reports

authors： Kim BR,Ha J,Kang E,Cho S

更新日期：2020-06-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...

journal_title：BMB reports

authors： Ziemienowicz A,Rahavi SM,Kovalchuk I

更新日期：2011-05-01 00:00:00

abstract：:Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related path...

journal_title：BMB reports

authors： Kim EC,Kim JR

更新日期：2019-01-01 00:00:00

abstract：:Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...

journal_title：BMB reports

authors： Yu NK,Kaang BK

更新日期：2016-04-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

journal_title：BMB reports

authors： Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

更新日期：2015-07-01 00:00:00

abstract：:A large data set of Hanwoo (Korean cattle) ESTs was analyzed to obtain differential gene expression results for the following three libraries: intramuscular fat, longissimus dorsi muscle and liver. To better understand the gene expression profiles, we identified differentially expressed genes (DEGs) via digital gene e...

journal_title：BMB reports

authors： Lim D,Lee SH,Cho YM,Yoon D,Shin Y,Kim KW,Park HS,Kim H

更新日期：2010-02-01 00:00:00

abstract：:The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...

journal_title：BMB reports

authors： Adibhatla RM,Hatcher JF

更新日期：2008-08-31 00:00:00