Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells.

abstract：:Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...

journal_title：BMB reports

authors： Park SW,Jun YW,Choi HE,Lee JA,Jang DJ

更新日期：2019-10-01 00:00:00

abstract：:Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...

journal_title：BMB reports

authors： Altintas O,Park S,Lee SJ

更新日期：2016-02-01 00:00:00

abstract：:Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...

journal_title：BMB reports

authors： Lee YJ,Kim JW

更新日期：2017-07-01 00:00:00

abstract：:We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

journal_title：BMB reports

authors： Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

更新日期：2017-12-01 00:00:00

abstract：:Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...

journal_title：BMB reports

authors： Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SK

更新日期：2011-07-01 00:00:00

abstract：:Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...

journal_title：BMB reports

authors： Solomon DA,Kim JS,Waldman T

更新日期：2014-06-01 00:00:00

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:In this study, we cloned the ERF-B3 subfamily transcription factor gene BnaERF-B3-hy15 from Brassica napus L. Huyou15. This 600 bp gene encodes a 199 amino acid classic ethylene responsive factor (ERF), which shown no binding or very weak binding GCC box-binding activity by the yeast one-hybrid assay. We used gene shu...

journal_title：BMB reports

authors： Jin XF,Zhu B,Peng RH,Jiang HH,Chen JM,Zhuang J,Zhang J,Yao QH,Xiong AS

更新日期：2010-08-01 00:00:00

abstract：:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...

journal_title：BMB reports

authors： Kim Y,Park S

更新日期：2011-02-01 00:00:00

abstract：:Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role ...

journal_title：BMB reports

authors： Hyun SY,Hwang HI,Jang YJ

更新日期：2014-05-01 00:00:00

abstract：:Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...

journal_title：BMB reports

authors： Kim YS,Lee SY,Yoon JW,Kim D,Yu S,Kim JS,Kim JH

更新日期：2020-11-01 00:00:00

abstract：:We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...

journal_title：BMB reports

authors： Ito Y,Hirano M,Umemoto N,Zang L,Wang Z,Oka T,Shimada Y,Nishimura Y,Kurokawa I,Mizutani H,Tanaka T

更新日期：2008-02-29 00:00:00

abstract：:Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...

journal_title：BMB reports

authors： Yeo H,Lee JY,Kim J,Ahn SS,Jeong JY,Choi JH,Lee YH,Shin SY

更新日期：2020-06-01 00:00:00

abstract：:Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipi...

journal_title：BMB reports

authors： Kumar S,Umair Z,Kumar V,Lee U,Choi SC,Kim J

更新日期：2019-06-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...

journal_title：BMB reports

authors： Adibhatla RM,Hatcher JF

更新日期：2008-08-31 00:00:00

abstract：:The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...

journal_title：BMB reports

authors： Cho HJ,Lee S,Kim H

更新日期：2009-11-30 00:00:00

abstract：:Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...

journal_title：BMB reports

authors： Park KC,Lee DC,Yeom YI

更新日期：2015-06-01 00:00:00

abstract：:The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...

journal_title：BMB reports

authors： Sinha M,Manna P,Sil PC

更新日期：2008-09-30 00:00:00

abstract：:Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...

journal_title：BMB reports

authors： Oh JH,Kim HJ,Kim TI,Woo KM

更新日期：2014-02-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...

journal_title：BMB reports

authors： Jang WG,Kim EJ,Koh JT

更新日期：2011-11-01 00:00:00

abstract：:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...

journal_title：BMB reports

authors： Kwon OS,Han MJ,Cha HJ

更新日期：2017-09-01 00:00:00

abstract：:Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...

journal_title：BMB reports

authors： Shanware NP,Williams LM,Bowler MJ,Tibbetts RS

更新日期：2009-03-31 00:00:00

abstract：:Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...

journal_title：BMB reports

authors： Kim MJ,Park SY,Chang HR,Jung EY,Munkhjargal A,Lim JS,Lee MS,Kim Y

更新日期：2017-06-01 00:00:00

abstract：:The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...

journal_title：BMB reports

authors： Park YJ,Lee JM,Shin SY,Kim YH

更新日期：2014-12-01 00:00:00

abstract：:Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...

journal_title：BMB reports

authors： Kang IS,Suh J,Lee MN,Lee C,Jin J,Lee C,Yang YI,Jang Y,Oh GT

更新日期：2020-02-01 00:00:00

abstract：:Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was a...

journal_title：BMB reports

authors： Li J,Li Y,Wang S,Che H,Wu J,Ren Y

更新日期：2019-09-01 00:00:00

abstract：:The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

journal_title：BMB reports

authors： Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

更新日期：2015-07-01 00:00:00

abstract：:The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...

journal_title：BMB reports

authors： Clack JW

更新日期：2008-07-31 00:00:00