Abstract:
:Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging. [BMB Reports 2016; 49(2): 81-92].
journal_name
BMB Repjournal_title
BMB reportsauthors
Altintas O,Park S,Lee SJdoi
10.5483/bmbrep.2016.49.2.261subject
Has Abstractpub_date
2016-02-01 00:00:00pages
81-92issue
2eissn
1976-6696issn
1976-670Xpii
3438journal_volume
49pub_type
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