Cancer immunotherapy: special issue of BMB Reports in 2021.


:Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigens, and exerts diverse effector functions to eliminate tumor cells. Anti-tumor immune responses resemble immune responses against viruses. In anti-tumor immune responses, CD8+ and CD4+ T cells are the main effector cells. In addition, dendritic cells (DCs) play a crucial role in the priming of CD8+ and CD4+ T cells, and natural killer (NK) cells also contribute to the anti-tumor immune responses. Recently, immune checkpoint inhibitors (ICIs), including antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA- 4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1), became available for the treatment of various types of cancer. Moreover, chimeric antigenic receptor (CAR)-T cells have been successfully used to treat hematologic malignancies. However, current cancer immunotherapy has some limitations. ICIs fail to control tumors in a considerable proportion of cancer patients and CAR-T cell therapy does not effectively control solid tumors. To overcome these limitations, further research and development are required. In the current issue of BMB Reports, seven review articles in the field of cancer immunotherapy were published. [BMB Reports 2021; 54(1): 1-1].




BMB reports


Shin EC


Has Abstract


2021-01-01 00:00:00














  • Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-conotoxin GIC.

    abstract::Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee C,Lee SH,Kim DH,Han KH

    更新日期:2012-05-01 00:00:00

  • Microorganism lipid droplets and biofuel development.

    abstract::Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Liu Y,Zhang C,Shen X,Zhang X,Cichello S,Guan H,Liu P

    更新日期:2013-12-01 00:00:00

  • Proline accumulation and transcriptional regulation of proline biosynthesis and degradation in Brassica napus.

    abstract::To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Xue X,Liu A,Hua X

    更新日期:2009-01-31 00:00:00

  • DAZL binds to the transcripts of several Tssk genes in germ cells.

    abstract::The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

    更新日期:2008-04-30 00:00:00

  • KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

    abstract::In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicate...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Hu J,Yuan W,Tang M,Wang Y,Fan X,Mo X,Li Y,Ying Z,Wan Y,Ocorr K,Bodmer R,Deng Y,Wu X

    更新日期:2010-01-01 00:00:00

  • TOMM20 as a potential therapeutic target of colorectal cancer.

    abstract::Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park SH,Lee AR,Choi K,Joung S,Yoon JB,Kim S

    更新日期:2019-12-01 00:00:00

  • AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells.

    abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

    更新日期:2014-08-01 00:00:00

  • Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production.

    abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

    更新日期:2009-12-31 00:00:00

  • Strengthened connections between engrams encode specific memories.

    abstract::In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Kim JI,Choi DI,Kaang BK

    更新日期:2018-08-01 00:00:00

  • Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of Hr(Hp) mice.

    abstract::Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SK

    更新日期:2011-07-01 00:00:00

  • SETDB1 regulates SMAD7 expression for breast cancer metastasis.

    abstract::Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Ryu TY,Kim K,Kim SK,Oh JH,Min JK,Jung CR,Son MY,Kim DS,Cho HS

    更新日期:2019-02-01 00:00:00

  • Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP+-dependent isocitrate dehydrogenase in HaCaT cells.

    abstract::Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee SJ,Park JW

    更新日期:2014-04-01 00:00:00

  • Inhibition of glutamate dehydrogenase and insulin secretion by KHG26377 does not involve ADP-ribosylation by SIRT4 or deacetylation by SIRT3.

    abstract::We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

    更新日期:2012-08-01 00:00:00

  • Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53.

    abstract::The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Lee EW,Oh W,Song HP,Kim WK

    更新日期:2017-07-01 00:00:00

  • ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation.

    abstract::Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen-activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: You Y,Li W,Gong Y,Yin B,Qiang B,Yuan J,Peng X

    更新日期:2010-07-01 00:00:00

  • IL-18 gene expression pattern in exogenously treated AML cells.

    abstract::IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expres...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Seo M,Park M,Yook Y,Kwon YS,Suh YJ,Kim MJ,Cho D,Park JH

    更新日期:2008-06-30 00:00:00

  • p13 from group II baculoviruses is a killing-associated gene.

    abstract::p13 gene was first described in Leucania separata multinuclear polyhedrosis virus (Ls-p13) several years ago, but the function of P13 protein has not been experimentally investigated to date. In this article, we indicated that the expression of p13 from Heliothis armigera single nucleocapsid nucleopolyhedrovirus (Ha-p...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lu N,Du E,Liu Y,Qiao H,Yao L,Pan Z,Lu S,Qi Y

    更新日期:2012-12-01 00:00:00

  • SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

    abstract::The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Luo N,Li G,Li Y,Fan X,Wang Y,Ye X,Mo X,Zhou J,Yuan W,Tan M,Xie H,Ocorr K,Bodmer R,Deng Y,Wu X

    更新日期:2010-05-01 00:00:00

  • Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.

    abstract::Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim MJ,Park SY,Chang HR,Jung EY,Munkhjargal A,Lim JS,Lee MS,Kim Y

    更新日期:2017-06-01 00:00:00

  • Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy.

    abstract::Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the devel...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Eom GH,Kook H

    更新日期:2015-03-01 00:00:00

  • Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer.

    abstract::We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

    更新日期:2017-12-01 00:00:00

  • The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity.

    abstract::The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Cho HJ,Lee S,Kim H

    更新日期:2009-11-30 00:00:00

  • Static tensional forces increase osteogenic gene expression in three-dimensional periodontal ligament cell culture.

    abstract::Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JY

    更新日期:2009-07-31 00:00:00

  • Upstream paths for Hippo signaling in Drosophila organ development.

    abstract::Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Choi KW

    更新日期:2018-03-01 00:00:00

  • Involvement of lymphoid inducer cells in the development of secondary and tertiary lymphoid structure.

    abstract::During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Evans I,Kim MY

    更新日期:2009-04-30 00:00:00

  • Comparative evaluation of the biological properties of fibrin for bone regeneration.

    abstract::Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Oh JH,Kim HJ,Kim TI,Woo KM

    更新日期:2014-02-01 00:00:00

  • Revisiting PPARγ as a target for the treatment of metabolic disorders.

    abstract::As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome pr...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Choi SS,Park J,Choi JH

    更新日期:2014-11-01 00:00:00

  • The nonconserved N-terminus of protein phosphatases 1 influences its active site.

    abstract::Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Xie X,Huang W,Xue C,Wei Q

    更新日期:2008-12-31 00:00:00

  • Systems biology of virus-host signaling network interactions.

    abstract::Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signali...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Xue Q,Miller-Jensen K

    更新日期:2012-04-01 00:00:00

  • Accelerating repaired basement membrane after bevacizumab treatment on alkali-burned mouse cornea.

    abstract::To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour an...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee KJ,Lee JY,Lee SH,Choi TH

    更新日期:2013-04-01 00:00:00