Abstract:
:Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription-polymerase chain reaction showed that NGF-induced Mac-2BP transcript levels were 4-5 times higher than in controls. Mac-2BP enzyme-linked immunosorbent assay and immunofluorescence staining showed a 2-3-fold increase in intracellular and secreted Mac-2BP as a result of NGF stimulation. This increase was regulated by Akt activation and NF-kappaB binding. p65 and p50-NF-kappaB are major transcriptional factors in the Mac-2BP promoter region, and were shown to be regulated in accordance with the Akt activation states. Collectively, these results suggest that NGF induces Mac-2BP expression via the PI3K/Akt/NF-kappaB pathway.
journal_name
BMB Repjournal_title
BMB reportsauthors
Park YP,Choi SC,Kim BY,Kim JT,Song EY,Kang SH,Yoon DY,Paik SG,Kim KD,Kim JW,Lee HGdoi
10.5483/bmbrep.2008.41.11.784subject
Has Abstractpub_date
2008-11-30 00:00:00pages
784-9issue
11eissn
1976-6696issn
1976-670Xjournal_volume
41pub_type
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