SETDB1 regulates SMAD7 expression for breast cancer metastasis.

Abstract:

:Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT /MET markers after knockdown of SETDB1. Moreover, gene network analysis showed that SMAD7 expression is regulated by SETDB1 levels, indicating that up-regulation of SMAD7 by SETDB1 knockdown inhibited BRC metastasis. Therefore, development of SETDB1 inhibitors and functional studies may help develop more effective clinical guidelines for BRC treatment. [BMB Reports 2019; 52(2): 139-144].

journal_name

BMB Rep

journal_title

BMB reports

authors

Ryu TY,Kim K,Kim SK,Oh JH,Min JK,Jung CR,Son MY,Kim DS,Cho HS

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

139-144

issue

2

eissn

1976-6696

issn

1976-670X

pii

4367

journal_volume

52

pub_type

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