FoxO3a mediates transforming growth factor-beta1-induced apoptosis in FaO rat hepatoma cells.

abstract：:Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445...

journal_title：BMB reports

authors： Lee T,Cho S,Seo KS,Chang J,Kim H,Yoon D

更新日期：2013-07-01 00:00:00

abstract：:Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...

journal_title：BMB reports

authors： Lee D,Lee JW

更新日期：2015-03-01 00:00:00

abstract：:Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...

journal_title：BMB reports

authors： Park SW,Jun YW,Choi HE,Lee JA,Jang DJ

更新日期：2019-10-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...

journal_title：BMB reports

authors： Xu H,Duan J,Ning D,Li J,Liu R,Yang R,Jiang JX,Shang P

更新日期：2014-12-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...

journal_title：BMB reports

authors： Choi YK,Tarazi FI

更新日期：2010-09-01 00:00:00

abstract：:Recent studies have reported that delayed-rectifier Kv channels regulate apoptosis in the nervous system. Herein, we investigated changes in the expression of the delayed-rectifier Kv channels Kv1.2, Kv2.1, and Kv3.1 after acute spinal cord injury (SCI) in rats. We performed RT-PCR analysis and found an increase in th...

journal_title：BMB reports

authors： Song MY,Moon YJ,Shin SK,Kim TY,Yune TY,Park KS

更新日期：2010-11-01 00:00:00

abstract：:To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour an...

journal_title：BMB reports

authors： Lee KJ,Lee JY,Lee SH,Choi TH

更新日期：2013-04-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

journal_title：BMB reports

authors： Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

更新日期：2015-09-01 00:00:00

abstract：:Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of ...

journal_title：BMB reports

authors： Kim BR,Ha J,Kang E,Cho S

更新日期：2020-06-01 00:00:00

abstract：:Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased ...

journal_title：BMB reports

authors： Moon Y,Park B,Park H

更新日期：2016-03-01 00:00:00

abstract：:To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

journal_title：BMB reports

authors： Xue X,Liu A,Hua X

更新日期：2009-01-31 00:00:00

abstract：:Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...

journal_title：BMB reports

authors： Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SK

更新日期：2011-07-01 00:00:00

abstract：:RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chroma...

journal_title：BMB reports

authors： Giraud G,Terrone S,Bourgeois CF

更新日期：2018-12-01 00:00:00

abstract：:DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

journal_title：BMB reports

authors： Park DS,Kim K,Jang M,Choi SC

更新日期：2018-12-01 00:00:00

abstract：:Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...

journal_title：BMB reports

authors： Shin EC

更新日期：2021-01-01 00:00:00

abstract：:All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...

journal_title：BMB reports

authors： Yoon YJ,Kim OY,Gho YS

更新日期：2014-10-01 00:00:00

abstract：:Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and lo...

journal_title：BMB reports

authors： Peng J

更新日期：2008-03-31 00:00:00

abstract：:Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...

journal_title：BMB reports

authors： Shanware NP,Williams LM,Bowler MJ,Tibbetts RS

更新日期：2009-03-31 00:00:00

abstract：:Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...

journal_title：BMB reports

authors： Kim YU,Kim YJ,Lee JY,Park K

更新日期：2013-08-01 00:00:00

abstract：:We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibi...

journal_title：BMB reports

authors： Cho KH

更新日期：2012-10-01 00:00:00

abstract：:Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...

journal_title：BMB reports

authors： Jang WG,Kim EJ,Koh JT

更新日期：2011-11-01 00:00:00

abstract：:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...

journal_title：BMB reports

authors： Kwon OS,Han MJ,Cha HJ

更新日期：2017-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....

journal_title：BMB reports

authors： Wang Y,Chen X,Yin Y,Li S

更新日期：2018-04-01 00:00:00

abstract：:Alternative splicing generates several interleukin-6 (IL-6) isoforms; for them an antagonistic activity to the wild-type IL-6 has been proposed. In this study we quantified the relative abundance of IL-6 mRNA isoforms in a panel of mouse tissues and in C2C12 cells during myoblast differentiation or after treatment wit...

journal_title：BMB reports

authors： Annibalini G,Guescini M,Agostini D,Matteis RD,Sestili P,Tibollo P,Mantuano M,Martinelli C,Stocchi V

更新日期：2012-01-01 00:00:00

abstract：:Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...

journal_title：BMB reports

authors： Jee H,Lee SH,Park JW,Lee BR,Nam KT,Kim DY

更新日期：2013-01-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegeneration. Oxidative modification of neurofilament proteins has been implicated in the pathogenesis of neurodegenerative disorders. In this study, oxidative m...

journal_title：BMB reports

authors： Kang JH

更新日期：2012-02-01 00:00:00

abstract：:Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...

journal_title：BMB reports

authors： Kim HE,Cho H,Ishihara A,Kim B,Kim O

更新日期：2018-04-01 00:00:00

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00