Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway.

abstract：:The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...

journal_title：BMB reports

authors： Jepson TA,Chung JK

更新日期：2021-01-07 00:00:00

abstract：:Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin...

journal_title：BMB reports

authors： Cui ZG,Hong NY,Guan J,Kang HK,Lee DH,Lee YK,Park DB

更新日期：2011-03-01 00:00:00

abstract：:Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

journal_title：BMB reports

authors： Yoo S

更新日期：2010-06-01 00:00:00

abstract：:Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on t...

journal_title：BMB reports

authors： Choe BI,Lee GH

更新日期：2017-12-01 00:00:00

abstract：:We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...

journal_title：BMB reports

authors： Yang Y,Chen L,Pan HZ,Kou Y,Xu CM

更新日期：2009-06-30 00:00:00

abstract：:The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...

journal_title：BMB reports

authors： Park YJ,Lee JM,Shin SY,Kim YH

更新日期：2014-12-01 00:00:00

abstract：:We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibi...

journal_title：BMB reports

authors： Cho KH

更新日期：2012-10-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipi...

journal_title：BMB reports

authors： Kumar S,Umair Z,Kumar V,Lee U,Choi SC,Kim J

更新日期：2019-06-01 00:00:00

abstract：:p13 gene was first described in Leucania separata multinuclear polyhedrosis virus (Ls-p13) several years ago, but the function of P13 protein has not been experimentally investigated to date. In this article, we indicated that the expression of p13 from Heliothis armigera single nucleocapsid nucleopolyhedrovirus (Ha-p...

journal_title：BMB reports

authors： Lu N,Du E,Liu Y,Qiao H,Yao L,Pan Z,Lu S,Qi Y

更新日期：2012-12-01 00:00:00

abstract：:Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...

journal_title：BMB reports

authors： Tran ST,Le DT,Kim YC,Shin M,Choi JD

更新日期：2009-08-31 00:00:00

abstract：:Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...

journal_title：BMB reports

authors： Kim MJ,Park SY,Chang HR,Jung EY,Munkhjargal A,Lim JS,Lee MS,Kim Y

更新日期：2017-06-01 00:00:00

abstract：:The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...

journal_title：BMB reports

authors： Sinha M,Manna P,Sil PC

更新日期：2008-09-30 00:00:00

abstract：:The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...

journal_title：BMB reports

authors： Hwang HS,Lee MH,Choi MH,Kim HA

更新日期：2019-06-01 00:00:00

abstract：:Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

journal_title：BMB reports

authors： Lee EW,Seo J,Jeong M,Lee S,Song J

更新日期：2012-09-01 00:00:00

abstract：:Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...

journal_title：BMB reports

authors： Jun J,Kim D

更新日期：2008-03-31 00:00:00

abstract：:The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...

journal_title：BMB reports

authors： Park S,Sim H,Lee K

更新日期：2016-01-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

journal_title：BMB reports

authors： Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

更新日期：2009-05-31 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...

journal_title：BMB reports

authors： Lee JS

更新日期：2019-01-01 00:00:00

abstract：:Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...

journal_title：BMB reports

authors： Solomon DA,Kim JS,Waldman T

更新日期：2014-06-01 00:00:00

abstract：:Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...

journal_title：BMB reports

authors： Hwang YJ,Song J,Kim HR,Hwang KA

更新日期：2014-09-01 00:00:00

abstract：:Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, ...

journal_title：BMB reports

authors： Lee Y

更新日期：2009-02-28 00:00:00

abstract：:The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...

journal_title：BMB reports

authors： Xu H,Duan J,Ning D,Li J,Liu R,Yang R,Jiang JX,Shang P

更新日期：2014-12-01 00:00:00

abstract：:Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. ...

journal_title：BMB reports

authors： Zheng FM,Chen WB,Qin T,Lv LN,Feng B,Lu YL,Li ZQ,Wang XC,Tao LJ,Li HW,Li SY

更新日期：2019-09-01 00:00:00

abstract：:The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155...

journal_title：BMB reports

authors： Lee EW,Oh W,Song HP,Kim WK

更新日期：2017-07-01 00:00:00

abstract：:Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...

journal_title：BMB reports

authors： Im CN,Seo JS

更新日期：2014-05-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...

journal_title：BMB reports

authors： Chen X,Sun Y,Cai R,Wang G,Shu X,Pang W

更新日期：2018-06-01 00:00:00

abstract：:Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...

journal_title：BMB reports

authors： Guo LL,He ZC,Yang CQ,Qiao PT,Yin GL

更新日期：2015-11-01 00:00:00