Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53.

abstract：:Cell proliferation is a delicately regulated process that couples growth signals and metabolic demands to produce daughter cells. Interestingly, the proliferation of tumor cells immensely depends on glycolysis, the Warburg effect, to ensure a sufficient amount of metabolic flux and bioenergetics for macromolecule synt...

journal_title：BMB reports

authors： Kee HJ,Cheong JH

更新日期：2014-03-01 00:00:00

abstract：:Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signali...

journal_title：BMB reports

authors： Xue Q,Miller-Jensen K

更新日期：2012-04-01 00:00:00

abstract：:Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the devel...

journal_title：BMB reports

authors： Eom GH,Kook H

更新日期：2015-03-01 00:00:00

abstract：:The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...

journal_title：BMB reports

authors： Hwang HS,Lee MH,Choi MH,Kim HA

更新日期：2019-06-01 00:00:00

abstract：:Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

journal_title：BMB reports

authors： Kim SJ,Chun KH

更新日期：2020-04-01 00:00:00

abstract：:Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...

journal_title：BMB reports

authors： Lee B,Shin YJ,Lee SM,Son YH,Yang YR,Lee KP

更新日期：2020-05-01 00:00:00

abstract：:The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

journal_title：BMB reports

authors： Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

更新日期：2017-05-01 00:00:00

abstract：:We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

journal_title：BMB reports

authors： Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

更新日期：2017-12-01 00:00:00

abstract：:Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...

journal_title：BMB reports

authors： Ryu TY,Kim K,Kim SK,Oh JH,Min JK,Jung CR,Son MY,Kim DS,Cho HS

更新日期：2019-02-01 00:00:00

abstract：:To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

journal_title：BMB reports

authors： Xue X,Liu A,Hua X

更新日期：2009-01-31 00:00:00

abstract：:Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

journal_title：BMB reports

authors： Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

更新日期：2009-05-31 00:00:00

abstract：:Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...

journal_title：BMB reports

authors： Jang HJ,Bak Y,Pham TH,Kwon SB,Kim BY,Hong J,Yoon DY

更新日期：2018-11-01 00:00:00

abstract：:Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...

journal_title：BMB reports

authors： Kim HE,Cho H,Ishihara A,Kim B,Kim O

更新日期：2018-04-01 00:00:00

abstract：:Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. ...

journal_title：BMB reports

authors： Gao X,Wang Q,Li W,Yang B,Song H,Ju W,Liu S,Cheng J

更新日期：2011-01-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for...

journal_title：BMB reports

authors： Lee SJ,Park JW

更新日期：2014-04-01 00:00:00

abstract：:The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...

journal_title：BMB reports

authors： Park S,Sim H,Lee K

更新日期：2016-01-01 00:00:00

abstract：:In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...

journal_title：BMB reports

authors： Shin J,Youn HD

更新日期：2016-10-01 00:00:00

abstract：:Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role ...

journal_title：BMB reports

authors： Hyun SY,Hwang HI,Jang YJ

更新日期：2014-05-01 00:00:00

abstract：:Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...

journal_title：BMB reports

authors： Yeo H,Lee JY,Kim J,Ahn SS,Jeong JY,Choi JH,Lee YH,Shin SY

更新日期：2020-06-01 00:00:00

abstract：:GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...

journal_title：BMB reports

authors： Kim JH

更新日期：2019-04-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other c...

journal_title：BMB reports

authors： Lejeune F

更新日期：2017-04-01 00:00:00

abstract：:Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...

journal_title：BMB reports

authors： Shirakawa J,Takegahara N,Kim H,Lee SH,Sato K,Yamagishi S,Choi Y

更新日期：2019-08-01 00:00:00

abstract：:Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-spec...

journal_title：BMB reports

authors： Baek JH,Kim NJ,Song JK,Chun KH

更新日期：2017-11-01 00:00:00

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00

abstract：:The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...

journal_title：BMB reports

authors： Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

更新日期：2009-12-31 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...

journal_title：BMB reports

authors： Xiao T,Xu Z,Zhang H,Geng J,Qiao Y,Liang Y,Yu Y,Dong Q,Suo G

更新日期：2019-06-01 00:00:00

abstract：:Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...

journal_title：BMB reports

authors： Oh JH,Kim HJ,Kim TI,Woo KM

更新日期：2014-02-01 00:00:00