Nonsense-mediated mRNA decay at the crossroads of many cellular pathways.


:Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition. [BMB Reports 2017; 50(4): 175-185].




BMB reports


Lejeune F




Has Abstract


2017-04-01 00:00:00














  • The roles of FADD in extrinsic apoptosis and necroptosis.

    abstract::Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Lee EW,Seo J,Jeong M,Lee S,Song J

    更新日期:2012-09-01 00:00:00

  • Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB.

    abstract::Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Gao X,Wang Q,Li W,Yang B,Song H,Ju W,Liu S,Cheng J

    更新日期:2011-01-01 00:00:00

  • p53 is not necessary for nuclear translocation of GAPDH during NO-induced apoptosis.

    abstract::Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in bot...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim JJ,Lee MY

    更新日期:2011-12-01 00:00:00

  • Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer.

    abstract::Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Kim Y,Jho EH

    更新日期:2017-06-01 00:00:00

  • Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of Hr(Hp) mice.

    abstract::Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SK

    更新日期:2011-07-01 00:00:00

  • Induction of Mac-2BP by nerve growth factor is regulated by the PI3K/Akt/NF-kappaB-dependent pathway in the HEK293 cell line.

    abstract::Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park YP,Choi SC,Kim BY,Kim JT,Song EY,Kang SH,Yoon DY,Paik SG,Kim KD,Kim JW,Lee HG

    更新日期:2008-11-30 00:00:00

  • Identification of a novel circularized transcript of the AML1 gene.

    abstract::The AML1 gene is an essential transcription factor regulating the differentiation of hematopoietic stem cells into mature blood cells. Though at least 12 different alternatively spliced AML1 mRNAs are generated, three splice variants (AML1a, AML1b and AML1c) have been characterized. Here, using the reverse transcripti...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Xu AN,Chen XH,Tan YH,Qi XL,Xu ZF,Zhang LL,Ren FG,Bian SC,Chen Y,Wang HW

    更新日期:2013-03-01 00:00:00

  • DNA methylation-based age prediction from various tissues and body fluids.

    abstract::Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Jung SE,Shin KJ,Lee HY

    更新日期:2017-11-01 00:00:00

  • Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis.

    abstract::Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Lee YJ,Kim JW

    更新日期:2017-07-01 00:00:00

  • The expanding reach of the GAL4/UAS system into the behavioral neurobiology of Drosophila.

    abstract::Our understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unp...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Jones WD

    更新日期:2009-11-30 00:00:00

  • A pheromone mutant of Schizosaccharomyces pombe displays nucleolar fragmentation.

    abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Jun J,Kim D

    更新日期:2008-03-31 00:00:00

  • Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia.

    abstract::Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Choi YK,Tarazi FI

    更新日期:2010-09-01 00:00:00

  • Systems biology of virus-host signaling network interactions.

    abstract::Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signali...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Xue Q,Miller-Jensen K

    更新日期:2012-04-01 00:00:00

  • Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages.

    abstract::Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatograph...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee J,Kim SL,Lee S,Chung MJ,Park YI

    更新日期:2014-07-01 00:00:00

  • Genetic variants and signatures of selective sweep of Hanwoo population (Korean native cattle).

    abstract::Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lee T,Cho S,Seo KS,Chang J,Kim H,Yoon D

    更新日期:2013-07-01 00:00:00

  • p13 from group II baculoviruses is a killing-associated gene.

    abstract::p13 gene was first described in Leucania separata multinuclear polyhedrosis virus (Ls-p13) several years ago, but the function of P13 protein has not been experimentally investigated to date. In this article, we indicated that the expression of p13 from Heliothis armigera single nucleocapsid nucleopolyhedrovirus (Ha-p...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Lu N,Du E,Liu Y,Qiao H,Yao L,Pan Z,Lu S,Qi Y

    更新日期:2012-12-01 00:00:00

  • ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity.

    abstract::In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB ...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Deng Y,Liu B,Fan X,Wang Y,Tang M,Mo X,Li Y,Ying Z,Wan Y,Luo N,Zhou J,Wu X,Yuan W

    更新日期:2010-03-01 00:00:00

  • EvoSNP-DB: A database of genetic diversity in East Asian populations.

    abstract::Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim YU,Kim YJ,Lee JY,Park K

    更新日期:2013-08-01 00:00:00

  • DAZL binds to the transcripts of several Tssk genes in germ cells.

    abstract::The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

    更新日期:2008-04-30 00:00:00

  • Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism.

    abstract::Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased ...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Moon Y,Park B,Park H

    更新日期:2016-03-01 00:00:00

  • NDRG3-mediated lactate signaling in hypoxia.

    abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park KC,Lee DC,Yeom YI

    更新日期:2015-06-01 00:00:00

  • Senotherapeutics: emerging strategy for healthy aging and age-related disease.

    abstract::Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related path...

    journal_title:BMB reports

    pub_type: 杂志文章,评审


    authors: Kim EC,Kim JR

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  • Characterization of full-length enriched expressed sequence tags of dehydration-treated white fibrous roots of sweetpotato.

    abstract::Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim SH,Song WK,Kim YH,Kwon SY,Lee HS,Lee IC,Kwak SS

    更新日期:2009-05-31 00:00:00

  • Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells.

    abstract::MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-me...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Cui X,Xu D,Lv C,Qu F,He J,Chen M,Liu Y,Gao Y,Che J,Yao Y,Yu H

    更新日期:2011-08-01 00:00:00

  • Role of dipeptidyl peptidase-4 as a potentiator of activin/nodal signaling pathway.

    abstract::DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park DS,Kim K,Jang M,Choi SC

    更新日期:2018-12-01 00:00:00

  • Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.

    abstract::Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Kim MJ,Park SY,Chang HR,Jung EY,Munkhjargal A,Lim JS,Lee MS,Kim Y

    更新日期:2017-06-01 00:00:00

  • Hemistepsin A inhibits T0901317-induced lipogenesis in the liver.

    abstract::Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...

    journal_title:BMB reports

    pub_type: 新闻


    authors: Kim JK,Cho IJ,Kim EO,Lee DG,Jung DH,Ki SH,Ku SK,Kim SC

    更新日期:2020-08-26 00:00:00

  • Genomic characterization of clonal evolution during oropharyngeal carcinogenesis driven by human papillomavirus 16.

    abstract::Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in or...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Chae J,Park WS,Kim MJ,Jang SS,Hong D,Ryu J,Ryu CH,Kim JH,Choi MK,Cho KH,Moon SH,Yun T,Kim JI,Jung YS

    更新日期:2018-11-01 00:00:00

  • C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells.

    abstract::Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Jegal ME,Jung SY,Han YS,Kim YJ

    更新日期:2019-05-01 00:00:00

  • Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells.

    abstract::The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...

    journal_title:BMB reports

    pub_type: 杂志文章


    authors: Park S,Sim H,Lee K

    更新日期:2016-01-01 00:00:00