Abstract:
:Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for antioxidant systems. In this study, we demonstrated that knockdown of IDPc expression by RNA interference enhances UVB-induced apoptosis of immortalized human HaCaT keratinocytes. This effect manifested as DNA fragmentation, changes in cellular redox status, mitochondrial dysfunction, and modulation of apoptotic marker expression. Based on our findings, we suggest that attenuation of IDPc expression may protect skin from UVB-mediated damage, by inducing the apoptosis of UV-damaged cells.
journal_name
BMB Repjournal_title
BMB reportsauthors
Lee SJ,Park JWdoi
10.5483/bmbrep.2014.47.4.137subject
Has Abstractpub_date
2014-04-01 00:00:00pages
209-14issue
4eissn
1976-6696issn
1976-670Xpii
2406journal_volume
47pub_type
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