Abstract:
:In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeLa cell lines. When these cell lines were transfected with HS1BP3, they exhibited nuclear DNA condensation, externalization of phosphatidylserine (PS), and cleavage of poly ADP ribose polymerase (PARP). Furthermore, suppression of HS1BP3 or HS1 expression attenuates HS1BP3 induced apoptosis. In addition, HS1BP3 enhanced activator protein 1 (AP-1)-mediated transcription in a dose-dependent manner. Therefore, we conclude that HS1BP3 regulates apoptosis via HS1 and stimulates AP-1-mediated transcription.
journal_name
BMB Repjournal_title
BMB reportsauthors
Shi T,Xie J,Xiong Y,Deng W,Guo J,Wang F,Ma Ddoi
10.5483/BMBRep.2011.44.6.381subject
Has Abstractpub_date
2011-06-01 00:00:00pages
381-6issue
6eissn
1976-6696issn
1976-670Xjournal_volume
44pub_type
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