Thrombin inhibits HMGB1-mediated proinflammatory signaling responses when endothelial protein C receptor is occupied by its natural ligand.

abstract：:Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in or...

journal_title：BMB reports

authors： Chae J,Park WS,Kim MJ,Jang SS,Hong D,Ryu J,Ryu CH,Kim JH,Choi MK,Cho KH,Moon SH,Yun T,Kim JI,Jung YS

更新日期：2018-11-01 00:00:00

abstract：:Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

journal_title：BMB reports

authors： Yoo S

更新日期：2010-06-01 00:00:00

abstract：:The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

journal_title：BMB reports

authors： Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

更新日期：2017-05-01 00:00:00

abstract：:Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of ...

journal_title：BMB reports

authors： Kim BR,Ha J,Kang E,Cho S

更新日期：2020-06-01 00:00:00

abstract：:Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display sho...

journal_title：BMB reports

authors： Chen H,Sun H,Tao D,Yang P,Bian S,Liu Y,Zhang S,Ma Y

更新日期：2014-01-01 00:00:00

abstract：:In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...

journal_title：BMB reports

authors： Shi T,Xie J,Xiong Y,Deng W,Guo J,Wang F,Ma D

更新日期：2011-06-01 00:00:00

abstract：:The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...

journal_title：BMB reports

authors： Ziemienowicz A,Rahavi SM,Kovalchuk I

更新日期：2011-05-01 00:00:00

abstract：:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...

journal_title：BMB reports

authors： Kwon OS,Han MJ,Cha HJ

更新日期：2017-09-01 00:00:00

abstract：:The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

journal_title：BMB reports

authors： Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

更新日期：2008-04-30 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...

journal_title：BMB reports

authors： Paik H,Ryu T,Heo HS,Seo SW,Lee D,Hur CG

更新日期：2011-04-01 00:00:00

abstract：:Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. ...

journal_title：BMB reports

authors： Gao X,Wang Q,Li W,Yang B,Song H,Ju W,Liu S,Cheng J

更新日期：2011-01-01 00:00:00

abstract：:GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...

journal_title：BMB reports

authors： Kim JH

更新日期：2019-04-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...

journal_title：BMB reports

authors： Choi YK,Tarazi FI

更新日期：2010-09-01 00:00:00

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...

journal_title：BMB reports

authors： Kim JI,Choi DI,Kaang BK

更新日期：2018-08-01 00:00:00

abstract：:Alternative splicing generates several interleukin-6 (IL-6) isoforms; for them an antagonistic activity to the wild-type IL-6 has been proposed. In this study we quantified the relative abundance of IL-6 mRNA isoforms in a panel of mouse tissues and in C2C12 cells during myoblast differentiation or after treatment wit...

journal_title：BMB reports

authors： Annibalini G,Guescini M,Agostini D,Matteis RD,Sestili P,Tibollo P,Mantuano M,Martinelli C,Stocchi V

更新日期：2012-01-01 00:00:00

abstract：:Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...

journal_title：BMB reports

authors： Kim Y,Jho EH

更新日期：2017-06-01 00:00:00

abstract：:Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

journal_title：BMB reports

authors： Lee EW,Seo J,Jeong M,Lee S,Song J

更新日期：2012-09-01 00:00:00

abstract：:Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...

journal_title：BMB reports

authors： Lee B,Shin YJ,Lee SM,Son YH,Yang YR,Lee KP

更新日期：2020-05-01 00:00:00

abstract：:Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...

journal_title：BMB reports

authors： Shirakawa J,Takegahara N,Kim H,Lee SH,Sato K,Yamagishi S,Choi Y

更新日期：2019-08-01 00:00:00

abstract：:Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...

journal_title：BMB reports

authors： Shin EC

更新日期：2021-01-01 00:00:00

abstract：:The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BA...

journal_title：BMB reports

authors： Klimenko OV,Vobruba V,Martasek P

更新日期：2010-04-01 00:00:00

abstract：:L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic f...

journal_title：BMB reports

authors： Kim IH,Kim DG,Hao P,Wang Y,Kim SH,Kim SW,Lee SO,Lee ST

更新日期：2012-06-01 00:00:00

abstract：:Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...

journal_title：BMB reports

authors： Liu Y,Zhang C,Shen X,Zhang X,Cichello S,Guan H,Liu P

更新日期：2013-12-01 00:00:00

abstract：:We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibi...

journal_title：BMB reports

authors： Cho KH

更新日期：2012-10-01 00:00:00

abstract：:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...

journal_title：BMB reports

authors： Kim Y,Park S

更新日期：2011-02-01 00:00:00

abstract：:The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...

journal_title：BMB reports

authors： Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

更新日期：2009-12-31 00:00:00

abstract：:Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...

journal_title：BMB reports

authors： Oh JH,Kim HJ,Kim TI,Woo KM

更新日期：2014-02-01 00:00:00

abstract：:DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

journal_title：BMB reports

authors： Park DS,Kim K,Jang M,Choi SC

更新日期：2018-12-01 00:00:00