Abstract:
:Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display shorter tails and necrosis with reduced expression of hematopoietic maker genes. Furthermore, we revealed that znf45l locates downstream of TGF-β ligands and maintains normal level of TGF-β receptor type II phosphorylation. In brief, our results indicate that znf45l affects initial hematopoietic development through regulation of TGF-β signaling.
journal_name
BMB Repjournal_title
BMB reportsauthors
Chen H,Sun H,Tao D,Yang P,Bian S,Liu Y,Zhang S,Ma Ydoi
10.5483/bmbrep.2014.47.1.048subject
Has Abstractpub_date
2014-01-01 00:00:00pages
21-6issue
1eissn
1976-6696issn
1976-670Xpii
2263journal_volume
47pub_type
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