Abstract:
:Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma. [BMB Reports 2019; 52(9): 566-571].
journal_name
BMB Repjournal_title
BMB reportsauthors
Zheng FM,Chen WB,Qin T,Lv LN,Feng B,Lu YL,Li ZQ,Wang XC,Tao LJ,Li HW,Li SYsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
566-571issue
9eissn
1976-6696issn
1976-670Xpii
4597journal_volume
52pub_type
新闻相关文献
BMB Reports文献大全abstract::Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.6.025
更新日期:2018-06-01 00:00:00
abstract::We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.2.139
更新日期:2008-02-29 00:00:00
abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.6.080
更新日期:2015-06-01 00:00:00
abstract::The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.7.077
更新日期:2017-07-01 00:00:00
abstract::In order to clarify the impact of Ca-binding sites (Ca1 and 2) on the conformational stability of neutral proteases (NPs), we have analyzed the thermal, pH and organic solvent stability of a NP variant, V189P/A195E/G203D/A268E (Q-mutant), from Salinovibrio proteolyticus. This mutant has shown to bind calcium more tigh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.10.665
更新日期:2011-10-01 00:00:00
abstract::Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.7.211
更新日期:2013-07-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is involved in the pathogenesis of vascular diseases. Unlike activated protein C (APC), the activation of PAR-1 by thrombin is known to elicit proinflammatory responses. To determine whether the occupancy of EPCR by the Gla-domain of APC is responsible for the PAR-1-dependent antiinfl...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.11.056
更新日期:2013-11-01 00:00:00
abstract::The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-12-01 00:00:00
abstract::The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-07 00:00:00
abstract::The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::In this study, we cloned the ERF-B3 subfamily transcription factor gene BnaERF-B3-hy15 from Brassica napus L. Huyou15. This 600 bp gene encodes a 199 amino acid classic ethylene responsive factor (ERF), which shown no binding or very weak binding GCC box-binding activity by the yeast one-hybrid assay. We used gene shu...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.8.567
更新日期:2010-08-01 00:00:00
abstract::The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.5.355
更新日期:2010-05-01 00:00:00
abstract::Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.2.113
更新日期:2011-02-01 00:00:00
abstract::Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-05-01 00:00:00
abstract::The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.5.341
更新日期:2011-05-01 00:00:00
abstract::Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...
journal_title:BMB reports
pub_type: 社论
doi:
更新日期:2019-01-01 00:00:00
abstract::Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.8.191
更新日期:2013-08-01 00:00:00
abstract::Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-spec...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.11.031
更新日期:2017-11-01 00:00:00
abstract::Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-11-01 00:00:00
abstract::During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2009.42.4.189
更新日期:2009-04-30 00:00:00
abstract::In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.1.017
更新日期:2010-01-01 00:00:00
abstract::Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-05-01 00:00:00
abstract::Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
abstract::Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipi...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.6.092
更新日期:2014-06-01 00:00:00
abstract::Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.9.578
更新日期:2011-09-01 00:00:00
abstract::Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-11-01 00:00:00
abstract::Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.9.119
更新日期:2017-09-01 00:00:00
abstract::Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-08-01 00:00:00