p13 from group II baculoviruses is a killing-associated gene.

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00

abstract：:The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

journal_title：BMB reports

authors： Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

更新日期：2008-04-30 00:00:00

abstract：:IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expres...

journal_title：BMB reports

authors： Seo M,Park M,Yook Y,Kwon YS,Suh YJ,Kim MJ,Cho D,Park JH

更新日期：2008-06-30 00:00:00

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

journal_title：BMB reports

authors： Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

更新日期：2015-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....

journal_title：BMB reports

authors： Wang Y,Chen X,Yin Y,Li S

更新日期：2018-04-01 00:00:00

abstract：:The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...

journal_title：BMB reports

authors： Shi HH,Liu HE,Luo XJ

更新日期：2020-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...

journal_title：BMB reports

authors： Xiao T,Xu Z,Zhang H,Geng J,Qiao Y,Liang Y,Yu Y,Dong Q,Suo G

更新日期：2019-06-01 00:00:00

abstract：:The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...

journal_title：BMB reports

authors： Ziemienowicz A,Rahavi SM,Kovalchuk I

更新日期：2011-05-01 00:00:00

abstract：:Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...

journal_title：BMB reports

authors： Lee D,Lee JW

更新日期：2015-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertroph...

journal_title：BMB reports

authors： Lee JS,Song DW,Park JH,Kim JO,Cho C,Kim DH

更新日期：2017-04-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other c...

journal_title：BMB reports

authors： Lejeune F

更新日期：2017-04-01 00:00:00

abstract：:Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...

journal_title：BMB reports

authors： Hwang YJ,Song J,Kim HR,Hwang KA

更新日期：2014-09-01 00:00:00

abstract：:We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...

journal_title：BMB reports

authors： Ito Y,Hirano M,Umemoto N,Zang L,Wang Z,Oka T,Shimada Y,Nishimura Y,Kurokawa I,Mizutani H,Tanaka T

更新日期：2008-02-29 00:00:00

abstract：:The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

journal_title：BMB reports

authors： Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

更新日期：2015-07-01 00:00:00

abstract：:In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...

journal_title：BMB reports

authors： Shin J,Youn HD

更新日期：2016-10-01 00:00:00

abstract：:Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...

journal_title：BMB reports

authors： Lee E,Jeong KW,Lee J,Shin A,Kim JK,Lee J,Lee DG,Kim Y

更新日期：2013-05-01 00:00:00

abstract：:Glucose effects on the vegetative growth of Dictyostelium discoideum Ax2 were studied by examining oxidative stress and tetrahydropteridine synthesis in cells cultured with different concentrations (0.5X, 7.7 g L(-1); 1X, 15.4 g L(-1); 2X, 30.8 g L(-1)) of glucose. The growth rate was optimal in 1X cells (cells grown ...

journal_title：BMB reports

authors： Park SO,Kim HL,Lee SW,Park YS

更新日期：2013-02-01 00:00:00

abstract：:Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...

journal_title：BMB reports

authors： Shin EC

更新日期：2021-01-01 00:00:00

abstract：:Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...

journal_title：BMB reports

authors： Park YP,Choi SC,Kim BY,Kim JT,Song EY,Kang SH,Yoon DY,Paik SG,Kim KD,Kim JW,Lee HG

更新日期：2008-11-30 00:00:00

abstract：:All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...

journal_title：BMB reports

authors： Yoon YJ,Kim OY,Gho YS

更新日期：2014-10-01 00:00:00

abstract：:Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...

journal_title：BMB reports

authors： Jung SE,Shin KJ,Lee HY

更新日期：2017-11-01 00:00:00

abstract：:The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...

journal_title：BMB reports

authors： Jepson TA,Chung JK

更新日期：2021-01-07 00:00:00

abstract：:High mobility group box 1 (HMGB1) is involved in the pathogenesis of vascular diseases. Unlike activated protein C (APC), the activation of PAR-1 by thrombin is known to elicit proinflammatory responses. To determine whether the occupancy of EPCR by the Gla-domain of APC is responsible for the PAR-1-dependent antiinfl...

journal_title：BMB reports

authors： Bae JS,Rezaie AR

更新日期：2013-11-01 00:00:00

abstract：:We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...

journal_title：BMB reports

authors： Yang Y,Chen L,Pan HZ,Kou Y,Xu CM

更新日期：2009-06-30 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...

journal_title：BMB reports

authors： Lee JS

更新日期：2019-01-01 00:00:00

abstract：:Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display sho...

journal_title：BMB reports

authors： Chen H,Sun H,Tao D,Yang P,Bian S,Liu Y,Zhang S,Ma Y

更新日期：2014-01-01 00:00:00

abstract：:The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...

journal_title：BMB reports

authors： Clack JW

更新日期：2008-07-31 00:00:00

abstract：:The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...

journal_title：BMB reports

authors： Hwang HS,Lee MH,Choi MH,Kim HA

更新日期：2019-06-01 00:00:00

abstract：:Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...

journal_title：BMB reports

authors： Liu Y,Zhang C,Shen X,Zhang X,Cichello S,Guan H,Liu P

更新日期：2013-12-01 00:00:00