Abstract:
:Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling.
journal_name
BMB Repjournal_title
BMB reportsauthors
Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SKdoi
10.5483/BMBRep.2011.44.7.478subject
Has Abstractpub_date
2011-07-01 00:00:00pages
478-83issue
7eissn
1976-6696issn
1976-670Xjournal_volume
44pub_type
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