Abstract:
:Skeletal muscle contracts or relaxes to maintain the body position and locomotion. For the contraction and relaxation of skeletal muscle, Ca2+ in the cytosol of skeletal muscle fibers acts as a switch to turn on and off a series of contractile proteins. The cytosolic Ca2+ level in skeletal muscle fibers is governed mainly by movements of Ca2+ between the cytosol and the sarcoplasmic reticulum (SR). Store-operated Ca2+ entry (SOCE), a Ca2+ entryway from the extracellular space to the cytosol, has gained a significant amount of attention from muscle physiologists. Orai1 and stromal interaction molecule 1 (STIM1) are the main protein identities of SOCE. This mini-review focuses on the roles of STIM proteins and SOCE in the physiological and pathophysiological functions of skeletal muscle and in their correlations with recently identified proteins, as well as historical proteins that are known to mediate skeletal muscle function. [BMB Reports 2018; 51(8): 378-387].
journal_name
BMB Repjournal_title
BMB reportsauthors
Cho CH,Lee KJ,Lee EHdoi
10.5483/bmbrep.2018.51.8.128subject
Has Abstractpub_date
2018-08-01 00:00:00pages
378-387issue
8eissn
1976-6696issn
1976-670Xpii
4230journal_volume
51pub_type
杂志文章,评审相关文献
BMB Reports文献大全abstract::Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.7.036
更新日期:2017-07-01 00:00:00
abstract::Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-01 00:00:00
abstract::Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related path...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-01-01 00:00:00
abstract::Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.11.784
更新日期:2008-11-30 00:00:00
abstract::LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD). LRRK2 pathogenic-specific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we constructed the LRRK2-prom...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.9.234
更新日期:2013-09-01 00:00:00
abstract::Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been stea...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.12.794
更新日期:2009-12-31 00:00:00
abstract::All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.10.164
更新日期:2014-10-01 00:00:00
abstract::Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-12-01 00:00:00
abstract::Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-08-26 00:00:00
abstract::Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-11-01 00:00:00
abstract::FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in FaO rat hepatoma cells. TGF-beta1 caused a time-dependent activation of ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.10.728
更新日期:2008-10-31 00:00:00
abstract::Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-08-01 00:00:00
abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.6.080
更新日期:2015-06-01 00:00:00
abstract::Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.6.059
更新日期:2017-06-01 00:00:00
abstract::The bactenecin is an antibacterial peptide with an intramolecular disulfide bond. We recently found that homodimeric bactenecin exhibits more potent antibacterial activity than the monomeric form and retains its activity at physiological conditions. Here we assess the difference in the modes of antibiotic action of ho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.9.586
更新日期:2009-09-30 00:00:00
abstract::The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.012
更新日期:2018-03-01 00:00:00
abstract::Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.027
更新日期:2018-03-01 00:00:00
abstract::Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...
journal_title:BMB reports
pub_type: 社论
doi:
更新日期:2019-01-01 00:00:00
abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.3.248
更新日期:2008-03-31 00:00:00
abstract::The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.6.276
更新日期:2012-06-01 00:00:00
abstract::The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2016.49.1.201
更新日期:2016-01-01 00:00:00
abstract::In the last decade, we have witnessed an unprecedented clinical success in cancer immunotherapies targeting the programmed cell-death ligand 1 (PD-L1) and programmed cell-death 1 (PD-1) pathway. Besides the fact that PD-L1 plays a key role in immune regulation in tumor microenvironment, recently a plethora of reports ...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-01 00:00:00
abstract::Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.6.092
更新日期:2014-06-01 00:00:00
abstract::Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-spec...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.11.031
更新日期:2017-11-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2018.51.4.005
更新日期:2018-04-01 00:00:00
abstract::In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.4.250
更新日期:2011-04-01 00:00:00
abstract::Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.8.191
更新日期:2013-08-01 00:00:00
abstract::Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was a...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-09-01 00:00:00