Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity.

abstract：:DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

journal_title：BMB reports

authors： Park DS,Kim K,Jang M,Choi SC

更新日期：2018-12-01 00:00:00

abstract：:Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...

journal_title：BMB reports

authors： Kim YS,Lee SY,Yoon JW,Kim D,Yu S,Kim JS,Kim JH

更新日期：2020-11-01 00:00:00

abstract：:Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...

journal_title：BMB reports

authors： Guo LL,He ZC,Yang CQ,Qiao PT,Yin GL

更新日期：2015-11-01 00:00:00

abstract：:Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...

journal_title：BMB reports

authors： Lee B,Shin YJ,Lee SM,Son YH,Yang YR,Lee KP

更新日期：2020-05-01 00:00:00

abstract：:The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

journal_title：BMB reports

authors： Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

更新日期：2017-05-01 00:00:00

abstract：:The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...

journal_title：BMB reports

authors： Park S,Sim H,Lee K

更新日期：2016-01-01 00:00:00

abstract：:The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...

journal_title：BMB reports

authors： Jepson TA,Chung JK

更新日期：2021-01-07 00:00:00

abstract：:Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...

journal_title：BMB reports

authors： Kim HY,Byun MJ,Kim H

更新日期：2011-09-01 00:00:00

abstract：:Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...

journal_title：BMB reports

authors： Kang IS,Suh J,Lee MN,Lee C,Jin J,Lee C,Yang YI,Jang Y,Oh GT

更新日期：2020-02-01 00:00:00

abstract：:The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...

journal_title：BMB reports

authors： Ziemienowicz A,Rahavi SM,Kovalchuk I

更新日期：2011-05-01 00:00:00

abstract：:Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...

journal_title：BMB reports

authors： Kim Y,Jho EH

更新日期：2017-06-01 00:00:00

abstract：:Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was a...

journal_title：BMB reports

authors： Li J,Li Y,Wang S,Che H,Wu J,Ren Y

更新日期：2019-09-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatograph...

journal_title：BMB reports

authors： Lee J,Kim SL,Lee S,Chung MJ,Park YI

更新日期：2014-07-01 00:00:00

abstract：:Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

journal_title：BMB reports

authors： Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

更新日期：2015-09-01 00:00:00

abstract：:Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signali...

journal_title：BMB reports

authors： Xue Q,Miller-Jensen K

更新日期：2012-04-01 00:00:00

abstract：:We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...

journal_title：BMB reports

authors： Ito Y,Hirano M,Umemoto N,Zang L,Wang Z,Oka T,Shimada Y,Nishimura Y,Kurokawa I,Mizutani H,Tanaka T

更新日期：2008-02-29 00:00:00

abstract：:Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...

journal_title：BMB reports

authors： Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JY

更新日期：2009-07-31 00:00:00

abstract：:Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...

journal_title：BMB reports

authors： Kim YU,Kim YJ,Lee JY,Park K

更新日期：2013-08-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...

journal_title：BMB reports

authors： Xiao T,Xu Z,Zhang H,Geng J,Qiao Y,Liang Y,Yu Y,Dong Q,Suo G

更新日期：2019-06-01 00:00:00

abstract：:The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...

journal_title：BMB reports

authors： Cho HJ,Lee S,Kim H

更新日期：2009-11-30 00:00:00

abstract：:Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...

journal_title：BMB reports

authors： Park YP,Choi SC,Kim BY,Kim JT,Song EY,Kang SH,Yoon DY,Paik SG,Kim KD,Kim JW,Lee HG

更新日期：2008-11-30 00:00:00

abstract：:Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin...

journal_title：BMB reports

authors： Cui ZG,Hong NY,Guan J,Kang HK,Lee DH,Lee YK,Park DB

更新日期：2011-03-01 00:00:00

abstract：:In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...

journal_title：BMB reports

authors： Shin J,Youn HD

更新日期：2016-10-01 00:00:00

abstract：:The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...

journal_title：BMB reports

authors： Hwang HS,Park IY,Kim DW,Choi SY,Jung YO,Kim HA

更新日期：2015-07-01 00:00:00

abstract：:The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...

journal_title：BMB reports

authors： Shi HH,Liu HE,Luo XJ

更新日期：2020-12-01 00:00:00

abstract：:All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...

journal_title：BMB reports

authors： Yoon YJ,Kim OY,Gho YS

更新日期：2014-10-01 00:00:00

abstract：:In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB ...

journal_title：BMB reports

authors： Deng Y,Liu B,Fan X,Wang Y,Tang M,Mo X,Li Y,Ying Z,Wan Y,Luo N,Zhou J,Wu X,Yuan W

更新日期：2010-03-01 00:00:00

abstract：:Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

journal_title：BMB reports

authors： Kim SJ,Chun KH

更新日期：2020-04-01 00:00:00

abstract：:Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...

journal_title：BMB reports

authors： Hwang YJ,Song J,Kim HR,Hwang KA

更新日期：2014-09-01 00:00:00