Systems biology of virus-host signaling network interactions.

abstract：:Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...

journal_title：BMB reports

authors： Tran ST,Le DT,Kim YC,Shin M,Choi JD

更新日期：2009-08-31 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...

journal_title：BMB reports

authors： Yoon YJ,Kim OY,Gho YS

更新日期：2014-10-01 00:00:00

abstract：:The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...

journal_title：BMB reports

authors： Shi HH,Liu HE,Luo XJ

更新日期：2020-12-01 00:00:00

abstract：:Arginine methylation plays crucial roles in many cellular functions including signal transduction, RNA transcription, and regulation of gene expression. Protein arginine methyltransferase 8 (PRMT8), a unique brain-specific protein, is localized to the plasma membrane. However, the detailed molecular mechanisms underly...

journal_title：BMB reports

authors： Park SW,Jun YW,Choi HE,Lee JA,Jang DJ

更新日期：2019-10-01 00:00:00

abstract：:The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...

journal_title：BMB reports

authors： Cho HJ,Lee S,Kim H

更新日期：2009-11-30 00:00:00

abstract：:In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...

journal_title：BMB reports

authors： Shi T,Xie J,Xiong Y,Deng W,Guo J,Wang F,Ma D

更新日期：2011-06-01 00:00:00

abstract：:Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...

journal_title：BMB reports

authors： Yoo S

更新日期：2010-06-01 00:00:00

abstract：:Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-spec...

journal_title：BMB reports

authors： Baek JH,Kim NJ,Song JK,Chun KH

更新日期：2017-11-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...

journal_title：BMB reports

authors： Lee JS

更新日期：2019-01-01 00:00:00

abstract：:Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...

journal_title：BMB reports

authors： Oh JH,Kim HJ,Kim TI,Woo KM

更新日期：2014-02-01 00:00:00

abstract：:Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...

journal_title：BMB reports

authors： Lee E,Jeong KW,Lee J,Shin A,Kim JK,Lee J,Lee DG,Kim Y

更新日期：2013-05-01 00:00:00

abstract：:Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...

journal_title：BMB reports

authors： Jun J,Kim D

更新日期：2008-03-31 00:00:00

abstract：:PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...

journal_title：BMB reports

authors： Kim DU,Yoo JH,Lee YJ,Kim KS,Cho HS

更新日期：2008-01-31 00:00:00

abstract：:The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...

journal_title：BMB reports

authors： Sinha M,Manna P,Sil PC

更新日期：2008-09-30 00:00:00

abstract：:The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

journal_title：BMB reports

authors： Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

更新日期：2008-04-30 00:00:00

abstract：:Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...

journal_title：BMB reports

authors： Chen X,Sun Y,Cai R,Wang G,Shu X,Pang W

更新日期：2018-06-01 00:00:00

abstract：:Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and lo...

journal_title：BMB reports

authors： Peng J

更新日期：2008-03-31 00:00:00

abstract：:Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...

journal_title：BMB reports

authors： Kim HY,Byun MJ,Kim H

更新日期：2011-09-01 00:00:00

abstract：:Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...

journal_title：BMB reports

authors： Jang HJ,Bak Y,Pham TH,Kwon SB,Kim BY,Hong J,Yoon DY

更新日期：2018-11-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...

journal_title：BMB reports

authors： Kim YS,Kim SH,Kang JG,Ko JH

更新日期：2012-11-01 00:00:00

abstract：:Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...

journal_title：BMB reports

authors： Kim YS,Lee SY,Yoon JW,Kim D,Yu S,Kim JS,Kim JH

更新日期：2020-11-01 00:00:00

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...

journal_title：BMB reports

authors： Shanware NP,Williams LM,Bowler MJ,Tibbetts RS

更新日期：2009-03-31 00:00:00

abstract：:Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...

journal_title：BMB reports

authors： Hwang YJ,Song J,Kim HR,Hwang KA

更新日期：2014-09-01 00:00:00

abstract：:The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BA...

journal_title：BMB reports

authors： Klimenko OV,Vobruba V,Martasek P

更新日期：2010-04-01 00:00:00

abstract：:The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...

journal_title：BMB reports

authors： Adibhatla RM,Hatcher JF

更新日期：2008-08-31 00:00:00

abstract：:Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...

journal_title：BMB reports

authors： Ryu TY,Kim K,Kim SK,Oh JH,Min JK,Jung CR,Son MY,Kim DS,Cho HS

更新日期：2019-02-01 00:00:00

abstract：:Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...

journal_title：BMB reports

authors： Liao ZQ,Ye M,Yu PG,Xiao C,Lin FY

更新日期：2016-07-01 00:00:00