Abstract:
:In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB domain and seven carboxyl-terminal C2H2 zinc finger motifs in the nucleus and cytoplasm. Northern blotting analysis indicated that a 2.3 kb transcript specific for ZNF552 was expressed in liver, lung, spleen, testis and kidney, especially with a higher level in the lung and testis in human adult tissues. Reporter gene assays showed that ZNF552 was a transcriptional repressor, and overexpression of ZNF552 in the COS-7 cells inhibited the transcriptional activities of AP-1 and SRE, which could be relieved through RNAi analysis. Deletion studies showed that the KRAB domain of ZNF552 may be involved in this inhibition.
journal_name
BMB Repjournal_title
BMB reportsauthors
Deng Y,Liu B,Fan X,Wang Y,Tang M,Mo X,Li Y,Ying Z,Wan Y,Luo N,Zhou J,Wu X,Yuan Wdoi
10.5483/bmbrep.2010.43.3.193subject
Has Abstractpub_date
2010-03-01 00:00:00pages
193-8issue
3eissn
1976-6696issn
1976-670Xjournal_volume
43pub_type
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