Abstract:
:Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver function biomarkers AST and ALT in 407 unrelated Koreans. We assayed the genome-wide variations on an Affymetrix Genome-Wide 6.0 array, and CNVs were analyzed using HelixTree. Using single linear regression, 32 and 42 CNVs showed significance for AST and ALT, respectively (P value < 0.05). We compared CNV-based genes between the current study (KARE2; AST-140, ALT-172) and KARE1 (AST-1885, ALT-773) using NetBox. Results showed 9 genes (CIDEB, DFFA, PSMA3, PSMC5, PSMC6, PSMD12, PSMF1, SDC4, and SIAH1) were overlapped for AST, but no overlapped genes were found for ALT. Functional gene annotation analysis shown the proteasome pathway, Wnt signaling pathway, programmed cell death, and protein binding.
journal_name
BMB Repjournal_title
BMB reportsauthors
Kim HY,Byun MJ,Kim Hdoi
10.5483/bmbrep.2011.44.9.578subject
Has Abstractpub_date
2011-09-01 00:00:00pages
578-83issue
9eissn
1976-6696issn
1976-670Xjournal_volume
44pub_type
杂志文章相关文献
BMB Reports文献大全abstract::GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-04-01 00:00:00
abstract::Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-08-01 00:00:00
abstract::Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2016.49.4.044
更新日期:2016-04-01 00:00:00
abstract::Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.11.735
更新日期:2011-11-01 00:00:00
abstract::The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.9.657
更新日期:2008-09-30 00:00:00
abstract::Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2018.51.4.005
更新日期:2018-04-01 00:00:00
abstract::Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.1.078
更新日期:2013-01-01 00:00:00
abstract::Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.6.025
更新日期:2018-06-01 00:00:00
abstract::Recent studies have reported that delayed-rectifier Kv channels regulate apoptosis in the nervous system. Herein, we investigated changes in the expression of the delayed-rectifier Kv channels Kv1.2, Kv2.1, and Kv3.1 after acute spinal cord injury (SCI) in rats. We performed RT-PCR analysis and found an increase in th...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2010.43.11.756
更新日期:2010-11-01 00:00:00
abstract::PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.1.048
更新日期:2008-01-31 00:00:00
abstract::LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD). LRRK2 pathogenic-specific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we constructed the LRRK2-prom...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.9.234
更新日期:2013-09-01 00:00:00
abstract::Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-11-01 00:00:00
abstract::Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS)...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.12.082
更新日期:2013-12-01 00:00:00
abstract::We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.6.331
更新日期:2009-06-30 00:00:00
abstract::Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.7.427
更新日期:2009-07-31 00:00:00
abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.159
更新日期:2014-08-01 00:00:00
abstract::In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.4.250
更新日期:2011-04-01 00:00:00
abstract::Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.12.881
更新日期:2008-12-31 00:00:00
abstract::Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in bot...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.12.782
更新日期:2011-12-01 00:00:00
abstract::Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.8.523
更新日期:2009-08-31 00:00:00
abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.12.794
更新日期:2009-12-31 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertroph...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.4.165
更新日期:2017-04-01 00:00:00
abstract::Cell proliferation is a delicately regulated process that couples growth signals and metabolic demands to produce daughter cells. Interestingly, the proliferation of tumor cells immensely depends on glycolysis, the Warburg effect, to ensure a sufficient amount of metabolic flux and bioenergetics for macromolecule synt...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.3.273
更新日期:2014-03-01 00:00:00
abstract::Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and lo...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2008.41.3.177
更新日期:2008-03-31 00:00:00
abstract::The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.11.764
更新日期:2009-11-30 00:00:00
abstract::Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.11.130
更新日期:2015-11-01 00:00:00
abstract::All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.10.164
更新日期:2014-10-01 00:00:00
abstract::Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.5.271
更新日期:2009-05-31 00:00:00
abstract::Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.11.784
更新日期:2008-11-30 00:00:00
abstract::Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-12-01 00:00:00