Abstract:
:Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases. [BMB Reports 2018; 51(6): 280-289].
journal_name
BMB Repjournal_title
BMB reportsauthors
Chen X,Sun Y,Cai R,Wang G,Shu X,Pang Wdoi
10.5483/bmbrep.2018.51.6.025subject
Has Abstractpub_date
2018-06-01 00:00:00pages
280-289issue
6eissn
1976-6696issn
1976-670Xpii
4092journal_volume
51pub_type
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