Promoting and improving three Rs practice: the Korean guidelines.

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, ...

journal_title：BMB reports

authors： Lee Y

更新日期：2009-02-28 00:00:00

abstract：:The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...

journal_title：BMB reports

authors： Xu H,Duan J,Ning D,Li J,Liu R,Yang R,Jiang JX,Shang P

更新日期：2014-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertroph...

journal_title：BMB reports

authors： Lee JS,Song DW,Park JH,Kim JO,Cho C,Kim DH

更新日期：2017-04-01 00:00:00

abstract：:Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...

journal_title：BMB reports

authors： Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JY

更新日期：2009-07-31 00:00:00

abstract：:RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chroma...

journal_title：BMB reports

authors： Giraud G,Terrone S,Bourgeois CF

更新日期：2018-12-01 00:00:00

abstract：:Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

journal_title：BMB reports

authors： Lee EW,Seo J,Jeong M,Lee S,Song J

更新日期：2012-09-01 00:00:00

abstract：:In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicate...

journal_title：BMB reports

authors： Hu J,Yuan W,Tang M,Wang Y,Fan X,Mo X,Li Y,Ying Z,Wan Y,Ocorr K,Bodmer R,Deng Y,Wu X

更新日期：2010-01-01 00:00:00

abstract：:Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...

journal_title：BMB reports

authors： Jung SE,Shin KJ,Lee HY

更新日期：2017-11-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...

journal_title：BMB reports

authors： Kim YU,Kim YJ,Lee JY,Park K

更新日期：2013-08-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologie...

journal_title：BMB reports

authors： Lee JS

更新日期：2019-01-01 00:00:00

abstract：:Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...

journal_title：BMB reports

authors： Guo LL,He ZC,Yang CQ,Qiao PT,Yin GL

更新日期：2015-11-01 00:00:00

abstract：:DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

journal_title：BMB reports

authors： Park DS,Kim K,Jang M,Choi SC

更新日期：2018-12-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the ...

journal_title：BMB reports

authors： Seo JW,Yang EJ,Kim SH,Choi IH

更新日期：2015-12-01 00:00:00

abstract：:Our understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unp...

journal_title：BMB reports

authors： Jones WD

更新日期：2009-11-30 00:00:00

abstract：:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...

journal_title：BMB reports

authors： Kwon OS,Han MJ,Cha HJ

更新日期：2017-09-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...

journal_title：BMB reports

authors： Choi YK,Tarazi FI

更新日期：2010-09-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...

journal_title：BMB reports

authors： Xiao T,Xu Z,Zhang H,Geng J,Qiao Y,Liang Y,Yu Y,Dong Q,Suo G

更新日期：2019-06-01 00:00:00

abstract：:Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...

journal_title：BMB reports

authors： Shanware NP,Williams LM,Bowler MJ,Tibbetts RS

更新日期：2009-03-31 00:00:00

abstract：:Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...

journal_title：BMB reports

authors： Im CN,Seo JS

更新日期：2014-05-01 00:00:00

abstract：:Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...

journal_title：BMB reports

authors： Park KC,Lee DC,Yeom YI

更新日期：2015-06-01 00:00:00

abstract：:Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...

journal_title：BMB reports

authors： Kim JK,Cho IJ,Kim EO,Lee DG,Jung DH,Ki SH,Ku SK,Kim SC

更新日期：2020-08-26 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...

journal_title：BMB reports

authors： Shi T,Xie J,Xiong Y,Deng W,Guo J,Wang F,Ma D

更新日期：2011-06-01 00:00:00

abstract：:Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The ce...

journal_title：BMB reports

authors： Mitchell RJ,Lee SK,Kim T,Ghim CM

更新日期：2011-01-01 00:00:00

abstract：:Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS)...

journal_title：BMB reports

authors： Park J,Park J,Nahm SS,Choi I,Kim J

更新日期：2013-12-01 00:00:00

abstract：:Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...

journal_title：BMB reports

authors： Jee H,Lee SH,Park JW,Lee BR,Nam KT,Kim DY

更新日期：2013-01-01 00:00:00

abstract：:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...

journal_title：BMB reports

authors： Kim Y,Park S

更新日期：2011-02-01 00:00:00