Abstract:
:RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chromatin modifiers and remodelers. However, to date, the variety of described mechanisms has made it difficult to understand precisely how these proteins work at the molecular level, and the contribution of their ATPase domain to these mechanisms remains unclear as well. In light of their association with long noncoding RNAs that are key epigenetic regulators, an emerging view is that DDX5 and DDX17 may act through modulating the activity of various ribonucleoprotein complexes that could ensure their targeting to specific chromatin loci. This review will comprehensively describe the current knowledge on these different mechanisms. We will also discuss the potential roles of DDX5 and DDX17 on the 3D chromatin organization and how these could impact gene expression at the transcriptional and post-transcriptional levels. [BMB Reports 2018; 51(12): 613-622].
journal_name
BMB Repjournal_title
BMB reportsauthors
Giraud G,Terrone S,Bourgeois CFsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
613-622issue
12eissn
1976-6696issn
1976-670Xpii
4366journal_volume
51pub_type
杂志文章,评审相关文献
BMB Reports文献大全abstract::Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.6.407
更新日期:2010-06-01 00:00:00
abstract::The bactenecin is an antibacterial peptide with an intramolecular disulfide bond. We recently found that homodimeric bactenecin exhibits more potent antibacterial activity than the monomeric form and retains its activity at physiological conditions. Here we assess the difference in the modes of antibiotic action of ho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.9.586
更新日期:2009-09-30 00:00:00
abstract::Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.9.578
更新日期:2011-09-01 00:00:00
abstract::Bisphosphonates are the mainstay of therapy worldwide for osteoporosis. However, bisphosphonates also have limitations. The objective of this study was to determine the role of miR-101-3p/Rap1b signal pathway in osteoclast differentiation after treatment with bisphosphonates. Our results revealed that miR-101-3p was a...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2019-09-01 00:00:00
abstract::Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.7.036
更新日期:2017-07-01 00:00:00
abstract::Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
abstract::GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-04-01 00:00:00
abstract::Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.11.130
更新日期:2015-11-01 00:00:00
abstract::We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.2.139
更新日期:2008-02-29 00:00:00
abstract::Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatograph...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.7.191
更新日期:2014-07-01 00:00:00
abstract::Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-11-01 00:00:00
abstract::The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.7.050
更新日期:2015-07-01 00:00:00
abstract::Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this ...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-12-01 00:00:00
abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.6.080
更新日期:2015-06-01 00:00:00
abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.3.248
更新日期:2008-03-31 00:00:00
abstract::Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display sho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.1.048
更新日期:2014-01-01 00:00:00
abstract::Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.3.205
更新日期:2011-03-01 00:00:00
abstract::Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.027
更新日期:2018-03-01 00:00:00
abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.12.794
更新日期:2009-12-31 00:00:00
abstract::Methylglyoxal (MG) was identified as an intermediate in non-enzymatic glycation and increased levels were reported in patients with diabetes. In this study, we evaluated the effects of MG on the modification of ferritin. When ferritin was incubated with MG, covalent crosslinking of the protein increased in a time- and...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2012.45.3.147
更新日期:2012-03-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertroph...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.4.165
更新日期:2017-04-01 00:00:00
abstract::The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2008-07-31 00:00:00
abstract::Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.3.047
更新日期:2015-03-01 00:00:00
abstract::The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.012
更新日期:2018-03-01 00:00:00
abstract::Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related path...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2019-01-01 00:00:00
abstract::A large data set of Hanwoo (Korean cattle) ESTs was analyzed to obtain differential gene expression results for the following three libraries: intramuscular fat, longissimus dorsi muscle and liver. To better understand the gene expression profiles, we identified differentially expressed genes (DEGs) via digital gene e...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.2.115
更新日期:2010-02-01 00:00:00
abstract::Cell therapies utilizing mesenchymal stem cells (MSCs) have a great potential in many research and clinical settings. The mechanisms underlying the therapeutic effects of MSCs have been studied previously and the paracrine effects elicited by their production of various growth factors and cytokines were recognized as ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.106
更新日期:2014-08-01 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.5.275
更新日期:2012-05-01 00:00:00
abstract::All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.10.164
更新日期:2014-10-01 00:00:00
abstract::The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.4.300
更新日期:2008-04-30 00:00:00