Abstract:
:Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to identify genes in human periodontal ligament (PDL) cells that undergo significant changes in expression in response to static tensional forces (2 or 12 hours). The genes found were alkaline phospatase (ALP), matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and several collagen genes. Furthermore, an ELISA evaluating the expression of VEGF, type IV collagen and MMP-2 found levels significantly increased after 24 and 72 hours (P 0.05). ALP activity was also increased after 24 hours (P 0.05). Collectively, we found the genes up-regulated in our study by the static tensional force are related to osteogenic processes such as matrix synthesis and angiogenesis.
journal_name
BMB Repjournal_title
BMB reportsauthors
Ku SJ,Chang YI,Chae CH,Kim SG,Park YW,Jung YK,Choi JYdoi
10.5483/bmbrep.2009.42.7.427subject
Has Abstractpub_date
2009-07-31 00:00:00pages
427-32issue
7eissn
1976-6696issn
1976-670Xjournal_volume
42pub_type
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