Abstract:
:Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain unclear. Cha et al. (2017) recently revealed that downregulation of SIRT2 by miR-200c enhances acetylation of glycolytic enzymes and glycolysis, which in turn facilitates cellular reprogramming, suggesting that SIRT2 is a key enzyme linking the metabolic switch and pluripotency in hPSCs. [BMB Reports 2017; 50(9): 435-436].
journal_name
BMB Repjournal_title
BMB reportsauthors
Kwon OS,Han MJ,Cha HJdoi
10.5483/bmbrep.2017.50.9.119subject
Has Abstractpub_date
2017-09-01 00:00:00pages
435-436issue
9eissn
1976-6696issn
1976-670Xpii
3906journal_volume
50pub_type
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