Abstract:
:We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibitory effects on cupric ion-mediated oxidation of lipoproteins in general, while simultaneously enhancing ferric ion removal ability in high-density lipoprotein (HDL). Hypercholesterolemia was induced in zebrafish using cholesterol-feeding treatment, 4% cholesterol, for 3 weeks. After feeding with or without the addition of cineole, the results revealed that cineole possessed lipid-lowering and anti-inflammatory activities in hypercholesterolemic zebrafish. In addition, serum amyloid A and interleukin-6 levels were lowered and lipid accumulation was decreased in the liver. Conclusively, 1,8-cineole was found to have anti-oxidant activities in lipoprotein metabolism both in vitro and in vivo with simultaneous reduction of lipid accumulation in the liver of zebrafish.
journal_name
BMB Repjournal_title
BMB reportsauthors
Cho KHdoi
10.5483/bmbrep.2012.45.10.044subject
Has Abstractpub_date
2012-10-01 00:00:00pages
565-70issue
10eissn
1976-6696issn
1976-670Xjournal_volume
45pub_type
杂志文章相关文献
BMB Reports文献大全abstract::Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2020-02-01 00:00:00
abstract::Basically, cancer is a disease initiated by mutations in the genome. However, cancer is regarded not only as a genetical disease but also an immunological disease because cancer cells can be targeted by the immune system. The immune system recognizes mutated proteins as non-self, foreign antigens, so-called neoantigen...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-01 00:00:00
abstract::MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-me...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.8.547
更新日期:2011-08-01 00:00:00
abstract::We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.8.040
更新日期:2012-08-01 00:00:00
abstract::In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.6.381
更新日期:2011-06-01 00:00:00
abstract::The AML1 gene is an essential transcription factor regulating the differentiation of hematopoietic stem cells into mature blood cells. Though at least 12 different alternatively spliced AML1 mRNAs are generated, three splice variants (AML1a, AML1b and AML1c) have been characterized. Here, using the reverse transcripti...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.3.171
更新日期:2013-03-01 00:00:00
abstract::The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.9.657
更新日期:2008-09-30 00:00:00
abstract::Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.12.881
更新日期:2008-12-31 00:00:00
abstract::Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.9.119
更新日期:2017-09-01 00:00:00
abstract::The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.5.201
更新日期:2017-05-01 00:00:00
abstract::All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.10.164
更新日期:2014-10-01 00:00:00
abstract::PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.1.048
更新日期:2008-01-31 00:00:00
abstract::Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.5.061
更新日期:2014-05-01 00:00:00
abstract::As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome pr...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.11.174
更新日期:2014-11-01 00:00:00
abstract::Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display sho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.1.048
更新日期:2014-01-01 00:00:00
abstract::The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2008-07-31 00:00:00
abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.159
更新日期:2014-08-01 00:00:00
abstract::Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.9.149
更新日期:2014-09-01 00:00:00
abstract::The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.12.193
更新日期:2014-12-01 00:00:00
abstract::We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.12.177
更新日期:2017-12-01 00:00:00
abstract::Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cel...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract::The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.10.655
更新日期:2009-10-31 00:00:00
abstract::Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of ...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-06-01 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.5.275
更新日期:2012-05-01 00:00:00
abstract::Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2012.45.9.186
更新日期:2012-09-01 00:00:00
abstract::Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.3.027
更新日期:2018-03-01 00:00:00
abstract::To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.1.028
更新日期:2009-01-31 00:00:00
abstract::Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:
更新日期:2020-04-01 00:00:00
abstract::Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.5.174
更新日期:2014-05-01 00:00:00
abstract::Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.1.078
更新日期:2013-01-01 00:00:00