Abstract:
:Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review.
journal_name
BMB Repjournal_title
BMB reportsauthors
Hyun SY,Hwang HI,Jang YJdoi
10.5483/bmbrep.2014.47.5.061subject
Has Abstractpub_date
2014-05-01 00:00:00pages
249-55issue
5eissn
1976-6696issn
1976-670Xpii
2741journal_volume
47pub_type
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