Abstract:
:IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NF(kappa)BIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NF(kappa)BIA is an inhibitor of NF(kappa)B, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.
journal_name
BMB Repjournal_title
BMB reportsauthors
Seo M,Park M,Yook Y,Kwon YS,Suh YJ,Kim MJ,Cho D,Park JHdoi
10.5483/bmbrep.2008.41.6.461subject
Has Abstractpub_date
2008-06-30 00:00:00pages
461-5issue
6eissn
1976-6696issn
1976-670Xjournal_volume
41pub_type
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