Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells.

abstract：:Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...

journal_title：BMB reports

authors： Jang WG,Kim EJ,Koh JT

更新日期：2011-11-01 00:00:00

abstract：:We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...

journal_title：BMB reports

authors： Kim EA,Yang SJ,Choi SY,Lee WJ,Cho SW

更新日期：2012-08-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is involved in the pathogenesis of vascular diseases. Unlike activated protein C (APC), the activation of PAR-1 by thrombin is known to elicit proinflammatory responses. To determine whether the occupancy of EPCR by the Gla-domain of APC is responsible for the PAR-1-dependent antiinfl...

journal_title：BMB reports

authors： Bae JS,Rezaie AR

更新日期：2013-11-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the ...

journal_title：BMB reports

authors： Seo JW,Yang EJ,Kim SH,Choi IH

更新日期：2015-12-01 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...

journal_title：BMB reports

authors： Shin HI,Chae KH,Cho TJ

更新日期：2013-10-01 00:00:00

abstract：:The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...

journal_title：BMB reports

authors： Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

更新日期：2009-12-31 00:00:00

abstract：:Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...

journal_title：BMB reports

authors： Lee ES,Seo HJ,Back SS,Han SH,Jeong YJ,Lee JW,Choi SY,Han K

更新日期：2015-09-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445...

journal_title：BMB reports

authors： Lee T,Cho S,Seo KS,Chang J,Kim H,Yoon D

更新日期：2013-07-01 00:00:00

abstract：:Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...

journal_title：BMB reports

authors： Liao ZQ,Ye M,Yu PG,Xiao C,Lin FY

更新日期：2016-07-01 00:00:00

abstract：:Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...

journal_title：BMB reports

authors： Kim Y,Jho EH

更新日期：2017-06-01 00:00:00

abstract：:Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...

journal_title：BMB reports

authors： Park SY,Kim YH,Kim YH,Park G,Lee SJ

更新日期：2010-12-01 00:00:00

abstract：:The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...

journal_title：BMB reports

authors： Zeng M,Deng W,Wang X,Qiu W,Liu Y,Sun H,Tao D,Zhang S,Ma Y

更新日期：2008-04-30 00:00:00

abstract：:Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, ...

journal_title：BMB reports

authors： Lee Y

更新日期：2009-02-28 00:00:00

abstract：:As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome pr...

journal_title：BMB reports

authors： Choi SS,Park J,Choi JH

更新日期：2014-11-01 00:00:00

abstract：:PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...

journal_title：BMB reports

authors： Kim DU,Yoo JH,Lee YJ,Kim KS,Cho HS

更新日期：2008-01-31 00:00:00

abstract：:To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

journal_title：BMB reports

authors： Xue X,Liu A,Hua X

更新日期：2009-01-31 00:00:00

abstract：:Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen-activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor ...

journal_title：BMB reports

authors： You Y,Li W,Gong Y,Yin B,Qiang B,Yuan J,Peng X

更新日期：2010-07-01 00:00:00

abstract：:GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requ...

journal_title：BMB reports

authors： Kim JH

更新日期：2019-04-01 00:00:00

abstract：:Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased ...

journal_title：BMB reports

authors： Moon Y,Park B,Park H

更新日期：2016-03-01 00:00:00

abstract：:Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...

journal_title：BMB reports

authors： Kim Y,Park S

更新日期：2011-02-01 00:00:00

abstract：:L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic f...

journal_title：BMB reports

authors： Kim IH,Kim DG,Hao P,Wang Y,Kim SH,Kim SW,Lee SO,Lee ST

更新日期：2012-06-01 00:00:00

abstract：:We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibi...

journal_title：BMB reports

authors： Cho KH

更新日期：2012-10-01 00:00:00

abstract：:Kv4.2, a pore-forming α-subunit of voltage-gated A-type potassium channels, is expressed abundantly in the soma and dendrites of hippocampal neurons, and is responsible for somatodendritic I(A) current. Recent studies have suggested that changes in the surface levels of Kv4.2 potassium channels might be relevant to sy...

journal_title：BMB reports

authors： Jo A,Nam YJ,Oh JY,Cheon HS,Jeromin A,Lee JA,Kim HK

更新日期：2010-10-01 00:00:00

abstract：:The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...

journal_title：BMB reports

authors： Luo N,Li G,Li Y,Fan X,Wang Y,Ye X,Mo X,Zhou J,Yuan W,Tan M,Xie H,Ocorr K,Bodmer R,Deng Y,Wu X

更新日期：2010-05-01 00:00:00

abstract：:Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...

journal_title：BMB reports

authors： Guo LL,He ZC,Yang CQ,Qiao PT,Yin GL

更新日期：2015-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....

journal_title：BMB reports

authors： Wang Y,Chen X,Yin Y,Li S

更新日期：2018-04-01 00:00:00

abstract：:In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...

journal_title：BMB reports

authors： Paik H,Ryu T,Heo HS,Seo SW,Lee D,Hur CG

更新日期：2011-04-01 00:00:00

abstract：:Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...

journal_title：BMB reports

authors： Lee E,Jeong KW,Lee J,Shin A,Kim JK,Lee J,Lee DG,Kim Y

更新日期：2013-05-01 00:00:00

abstract：:LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD). LRRK2 pathogenic-specific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we constructed the LRRK2-prom...

journal_title：BMB reports

authors： Park JM,Ho DH,Yun HJ,Kim HJ,Lee CH,Park SW,Kim YH,Son I,Seol W

更新日期：2013-09-01 00:00:00