Abstract:
:Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases.
journal_name
BMB Repjournal_title
BMB reportsauthors
Jeon S,Oh IHdoi
10.5483/bmbrep.2015.48.4.276subject
Has Abstractpub_date
2015-04-01 00:00:00pages
193-9issue
4eissn
1976-6696issn
1976-670Xpii
3028journal_volume
48pub_type
杂志文章,评审相关文献
BMB Reports文献大全abstract::MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-me...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.8.547
更新日期:2011-08-01 00:00:00
abstract::Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.2.156
更新日期:2014-02-01 00:00:00
abstract::The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2008-07-31 00:00:00
abstract::Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.6.078
更新日期:2017-06-01 00:00:00
abstract::Our understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unp...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2009.42.11.705
更新日期:2009-11-30 00:00:00
abstract::During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2009.42.4.189
更新日期:2009-04-30 00:00:00
abstract::The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.12.017
更新日期:2014-12-01 00:00:00
abstract::Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.8.523
更新日期:2009-08-31 00:00:00
abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.3.248
更新日期:2008-03-31 00:00:00
abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.6.080
更新日期:2015-06-01 00:00:00
abstract::In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.4.250
更新日期:2011-04-01 00:00:00
abstract::Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2012.45.11.233
更新日期:2012-11-01 00:00:00
abstract::Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.9.578
更新日期:2011-09-01 00:00:00
abstract::Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the m...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-05-01 00:00:00
abstract::The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cas...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2021-01-07 00:00:00
abstract::FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in FaO rat hepatoma cells. TGF-beta1 caused a time-dependent activation of ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.10.728
更新日期:2008-10-31 00:00:00
abstract::Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2016.49.2.261
更新日期:2016-02-01 00:00:00
abstract::Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.10.046
更新日期:2013-10-01 00:00:00
abstract::Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.5.174
更新日期:2014-05-01 00:00:00
abstract::Dorsoventral patterning of body axis in vertebrate embryo is tightly controlled by a complex regulatory network of transcription factors. Ventx1.1 is known as a transcriptional repressor to inhibit dorsal mesoderm formation and neural differentiation in Xenopus. In an attempt to identify, using chromatin immunoprecipi...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether s...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2018-08-01 00:00:00
abstract::In order to clarify the impact of Ca-binding sites (Ca1 and 2) on the conformational stability of neutral proteases (NPs), we have analyzed the thermal, pH and organic solvent stability of a NP variant, V189P/A195E/G203D/A268E (Q-mutant), from Salinovibrio proteolyticus. This mutant has shown to bind calcium more tigh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.10.665
更新日期:2011-10-01 00:00:00
abstract::The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2008.41.8.560
更新日期:2008-08-31 00:00:00
abstract::In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.1.017
更新日期:2010-01-01 00:00:00
abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.159
更新日期:2014-08-01 00:00:00
abstract::Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte prol...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2018.51.4.209
更新日期:2018-04-01 00:00:00
abstract::The N-myc downstream regulated gene (NDRG) family members are dysregulated in several tumors. Functionally, NDRGs play an important role in the malignant progression of cancer cells. However, little is known about the potential implications of NDRG4 in pancreatic ductal adenocarcinoma (PDAC). The aim of the current st...
journal_title:BMB reports
pub_type: 新闻
doi:
更新日期:2020-12-01 00:00:00
abstract::Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS)...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.12.082
更新日期:2013-12-01 00:00:00
abstract::Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2018.51.6.025
更新日期:2018-06-01 00:00:00
abstract::Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.6.059
更新日期:2017-06-01 00:00:00