Modification of Turnip yellow mosaic virus coat protein and its effect on virion assembly.

abstract：:Matrix metalloproteinase 1 (MMP-1), a calcium-dependent zinccontaining collagenase, is involved in the initial degradation of native fibrillar collagen. Tissue necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine that is rapidly produced by dermal fibroblasts, monocytes/macrophages, and keratinocytes and regula...

journal_title：BMB reports

authors： Yeo H,Lee JY,Kim J,Ahn SS,Jeong JY,Choi JH,Lee YH,Shin SY

更新日期：2020-06-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatme...

journal_title：BMB reports

authors： Xiao T,Xu Z,Zhang H,Geng J,Qiao Y,Liang Y,Yu Y,Dong Q,Suo G

更新日期：2019-06-01 00:00:00

abstract：:Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...

journal_title：BMB reports

authors： Kim MJ,Park SY,Chang HR,Jung EY,Munkhjargal A,Lim JS,Lee MS,Kim Y

更新日期：2017-06-01 00:00:00

abstract：:The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...

journal_title：BMB reports

authors： Adibhatla RM,Hatcher JF

更新日期：2008-08-31 00:00:00

abstract：:Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been stea...

journal_title：BMB reports

authors： Park J,Lee DH

更新日期：2020-04-01 00:00:00

abstract：:Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...

journal_title：BMB reports

authors： Shanware NP,Williams LM,Bowler MJ,Tibbetts RS

更新日期：2009-03-31 00:00:00

abstract：:The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix ad...

journal_title：BMB reports

authors： Seo J,Kim J

更新日期：2018-03-01 00:00:00

abstract：:Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...

journal_title：BMB reports

authors： Choi JH,Kim BK,Kim JK,Lee HY,Park JK,Yoon SK

更新日期：2011-07-01 00:00:00

abstract：:Skeletal muscle contracts or relaxes to maintain the body position and locomotion. For the contraction and relaxation of skeletal muscle, Ca2＋ in the cytosol of skeletal muscle fibers acts as a switch to turn on and off a series of contractile proteins. The cytosolic Ca2＋ level in skeletal muscle fibers is governed ma...

journal_title：BMB reports

authors： Cho CH,Lee KJ,Lee EH

更新日期：2018-08-01 00:00:00

abstract：:Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...

journal_title：BMB reports

authors： Xie X,Huang W,Xue C,Wei Q

更新日期：2008-12-31 00:00:00

abstract：:Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...

journal_title：BMB reports

authors： Lee EW,Seo J,Jeong M,Lee S,Song J

更新日期：2012-09-01 00:00:00

abstract：:Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Alt...

journal_title：BMB reports

authors： Jeon S,Oh IH

更新日期：2015-04-01 00:00:00

abstract：:Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The ce...

journal_title：BMB reports

authors： Mitchell RJ,Lee SK,Kim T,Ghim CM

更新日期：2011-01-01 00:00:00

abstract：:Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...

journal_title：BMB reports

authors： Jung SE,Shin KJ,Lee HY

更新日期：2017-11-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...

journal_title：BMB reports

authors： Kim YU,Kim YJ,Lee JY,Park K

更新日期：2013-08-01 00:00:00

abstract：:We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at variou...

journal_title：BMB reports

authors： Paek AR,Mun JY,Hong KM,Lee J,Hong DW,You HJ

更新日期：2017-12-01 00:00:00

abstract：:The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...

journal_title：BMB reports

authors： Park YJ,Lee JM,Shin SY,Kim YH

更新日期：2014-12-01 00:00:00

abstract：:Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...

journal_title：BMB reports

authors： Lee YJ,Kim JW

更新日期：2017-07-01 00:00:00

abstract：:The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understan...

journal_title：BMB reports

authors： Ryoo HD,Vasudevan D

更新日期：2017-11-01 00:00:00

abstract：:Galectin-3 is a carbohydrate-binding protein and regulates diverse functions, including cell proliferation and differentiation, mRNA splicing, apoptosis induction, immune surveillance and inflammation, cell adhesion, angiogenesis, and cancer-cell metastasis. Galectin-3 is also recommended as a diagnostic or prognostic...

journal_title：BMB reports

authors： Kim SJ,Chun KH

更新日期：2020-04-01 00:00:00

abstract：:Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in or...

journal_title：BMB reports

authors： Chae J,Park WS,Kim MJ,Jang SS,Hong D,Ryu J,Ryu CH,Kim JH,Choi MK,Cho KH,Moon SH,Yun T,Kim JI,Jung YS

更新日期：2018-11-01 00:00:00

abstract：:IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expres...

journal_title：BMB reports

authors： Seo M,Park M,Yook Y,Kwon YS,Suh YJ,Kim MJ,Cho D,Park JH

更新日期：2008-06-30 00:00:00

abstract：:Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...

journal_title：BMB reports

authors： Choi KW

更新日期：2018-03-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other c...

journal_title：BMB reports

authors： Lejeune F

更新日期：2017-04-01 00:00:00

abstract：:To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...

journal_title：BMB reports

authors： Xue X,Liu A,Hua X

更新日期：2009-01-31 00:00:00

abstract：:Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....

journal_title：BMB reports

authors： Im JY,Min WK,Park MH,Kim N,Lee JK,Jin HK,Choi JY,Kim SY,Bae JS

更新日期：2014-08-01 00:00:00

abstract：:The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...

journal_title：BMB reports

authors： Park S,Sim H,Lee K

更新日期：2016-01-01 00:00:00

abstract：:In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...

journal_title：BMB reports

authors： Paik H,Ryu T,Heo HS,Seo SW,Lee D,Hur CG

更新日期：2011-04-01 00:00:00

abstract：:Recent studies have reported that delayed-rectifier Kv channels regulate apoptosis in the nervous system. Herein, we investigated changes in the expression of the delayed-rectifier Kv channels Kv1.2, Kv2.1, and Kv3.1 after acute spinal cord injury (SCI) in rats. We performed RT-PCR analysis and found an increase in th...

journal_title：BMB reports

authors： Song MY,Moon YJ,Shin SK,Kim TY,Yune TY,Park KS

更新日期：2010-11-01 00:00:00

abstract：:The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis...

journal_title：BMB reports

authors： Hwang HS,Lee MH,Choi MH,Kim HA

更新日期：2019-06-01 00:00:00