Abstract:
:Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effects of fibrin and collagen on the proliferation and differentiation of osteoblasts and protein adsorption. Compared to collagen, fibrin adsorbed approximately 6.7 times more serum fibronectin. Moreover, fibrin allowed the proliferation of larger MC3T3-E1 pre-osteoblasts, especially at a low cell density. Fibrin promoted osteoblast differentiation at higher levels than collagen, as confirmed by Runx2 expression and transcriptional activity, alkaline phosphatase activity, and calcium deposition. The results of the present study suggest that fibrin is superior to collagen in the support of bone regeneration.
journal_name
BMB Repjournal_title
BMB reportsauthors
Oh JH,Kim HJ,Kim TI,Woo KMdoi
10.5483/bmbrep.2014.47.2.156subject
Has Abstractpub_date
2014-02-01 00:00:00pages
110-4issue
2eissn
1976-6696issn
1976-670Xpii
2438journal_volume
47pub_type
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