Abstract:
:Our understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unprecedented level of control over fly neural circuits. Efforts are underway to add to existing GAL4-driver lines that permit exogenous expression of genetic tools in small populations of neurons. Combining these driver lines with a variety of inducible UAS lines permits the visualization of neuronal morphology, connectivity, and activity. These driver lines also make it possible to specifically ablate, inhibit, or activate subsets of neurons and assess their roles in the generation of behavioral responses. Here, I will briefly review the extensive arsenal now available to drosophilists for investigating the neuronal control of behavior.
journal_name
BMB Repjournal_title
BMB reportsauthors
Jones WDdoi
10.5483/bmbrep.2009.42.11.705subject
Has Abstractpub_date
2009-11-30 00:00:00pages
705-12issue
11eissn
1976-6696issn
1976-670Xjournal_volume
42pub_type
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