Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides.

abstract：:Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...

journal_title：BMB reports

authors： Solomon DA,Kim JS,Waldman T

更新日期：2014-06-01 00:00:00

abstract：:The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...

journal_title：BMB reports

authors： Xu H,Duan J,Ning D,Li J,Liu R,Yang R,Jiang JX,Shang P

更新日期：2014-12-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...

journal_title：BMB reports

authors： Lee C,Lee SH,Kim DH,Han KH

更新日期：2012-05-01 00:00:00

abstract：:In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...

journal_title：BMB reports

authors： Shi T,Xie J,Xiong Y,Deng W,Guo J,Wang F,Ma D

更新日期：2011-06-01 00:00:00

abstract：:Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...

journal_title：BMB reports

authors： Altintas O,Park S,Lee SJ

更新日期：2016-02-01 00:00:00

abstract：:The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...

journal_title：BMB reports

authors： Adibhatla RM,Hatcher JF

更新日期：2008-08-31 00:00:00

abstract：:Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchym...

journal_title：BMB reports

authors： Kang IS,Suh J,Lee MN,Lee C,Jin J,Lee C,Yang YI,Jang Y,Oh GT

更新日期：2020-02-01 00:00:00

abstract：:Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-...

journal_title：BMB reports

authors： Kim YS,Lee SY,Yoon JW,Kim D,Yu S,Kim JS,Kim JH

更新日期：2020-11-01 00:00:00

abstract：:The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...

journal_title：BMB reports

authors： Ziemienowicz A,Rahavi SM,Kovalchuk I

更新日期：2011-05-01 00:00:00

abstract：:The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...

journal_title：BMB reports

authors： Lee BR,Kim SY,Kim DW,An JJ,Song HY,Yoo KY,Kang TC,Won MH,Lee KJ,Kim KH,Joo JH,Ham HJ,Hur JH,Cho SW,Han KH,Lee KS,Park J,Choi SY,Eum WS

更新日期：2009-12-31 00:00:00

abstract：:The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. The full-length cDNA was 2204 base pair (bp) and contained a single 1968 bp ORF that encoded a polypeptide of 656 amino acids with a predicted molecular mass of 71.28 kDa. Phylogenetic analysis base...

journal_title：BMB reports

authors： Wang H,Dong SZ,Li K,Hu C,Ye GY

更新日期：2008-05-31 00:00:00

abstract：:DPP4 (dipeptidyl peptidase-4), a highly conserved transmembrane glycoprotein with an exo-peptidase activity, has been shown to contribute to glucose metabolism, immune regulation, signal transduction, and cell differentiation. Here, we show that DPP4 is involved in control of activin/nodal signaling in Xenopus early d...

journal_title：BMB reports

authors： Park DS,Kim K,Jang M,Choi SC

更新日期：2018-12-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell tra...

journal_title：BMB reports

authors： Iqbal MA,Hong K,Kim JH,Choi Y

更新日期：2019-11-01 00:00:00

abstract：:The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...

journal_title：BMB reports

authors： Sinha M,Manna P,Sil PC

更新日期：2008-09-30 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs....

journal_title：BMB reports

authors： Wang Y,Chen X,Yin Y,Li S

更新日期：2018-04-01 00:00:00

abstract：:FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in FaO rat hepatoma cells. TGF-beta1 caused a time-dependent activation of ...

journal_title：BMB reports

authors： Kim BC

更新日期：2008-10-31 00:00:00

abstract：:The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...

journal_title：BMB reports

authors： Luo N,Li G,Li Y,Fan X,Wang Y,Ye X,Mo X,Zhou J,Yuan W,Tan M,Xie H,Ocorr K,Bodmer R,Deng Y,Wu X

更新日期：2010-05-01 00:00:00

abstract：:Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...

journal_title：BMB reports

authors： Jee H,Lee SH,Park JW,Lee BR,Nam KT,Kim DY

更新日期：2013-01-01 00:00:00

abstract：:Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS)...

journal_title：BMB reports

authors： Park J,Park J,Nahm SS,Choi I,Kim J

更新日期：2013-12-01 00:00:00

abstract：:Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and po...

journal_title：BMB reports

authors： Chen X,Sun Y,Cai R,Wang G,Shu X,Pang W

更新日期：2018-06-01 00:00:00

abstract：:The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...

journal_title：BMB reports

authors： Park YH,Jeong MS,Ha KT,Yu HS,Jang SB

更新日期：2017-05-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the ...

journal_title：BMB reports

authors： Seo JW,Yang EJ,Kim SH,Choi IH

更新日期：2015-12-01 00:00:00

abstract：:Organ growth is fundamental to animal development. One of major mechanisms for growth control is mediated by the conserved Hippo signaling pathway initially identified in Drosophila. The core of this pathway in Drosophila consists of a cascade of protein kinases Hippo and Warts that negatively regulate transcriptional...

journal_title：BMB reports

authors： Choi KW

更新日期：2018-03-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for...

journal_title：BMB reports

authors： Lee SJ,Park JW

更新日期：2014-04-01 00:00:00

abstract：:Hemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in vitro and in vivo. Up to 10 M, HsA did not affect the viability of HepG2 and Huh7 cells. Pretreatment with 5-10 μM HsA signif...

journal_title：BMB reports

authors： Kim JK,Cho IJ,Kim EO,Lee DG,Jung DH,Ki SH,Ku SK,Kim SC

更新日期：2020-08-26 00:00:00

abstract：:The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...

journal_title：BMB reports

authors： Cho HJ,Lee S,Kim H

更新日期：2009-11-30 00:00:00

abstract：:p13 gene was first described in Leucania separata multinuclear polyhedrosis virus (Ls-p13) several years ago, but the function of P13 protein has not been experimentally investigated to date. In this article, we indicated that the expression of p13 from Heliothis armigera single nucleocapsid nucleopolyhedrovirus (Ha-p...

journal_title：BMB reports

authors： Lu N,Du E,Liu Y,Qiao H,Yao L,Pan Z,Lu S,Qi Y

更新日期：2012-12-01 00:00:00

abstract：:In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...

journal_title：BMB reports

authors： Paik H,Ryu T,Heo HS,Seo SW,Lee D,Hur CG

更新日期：2011-04-01 00:00:00

abstract：:The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...

journal_title：BMB reports

authors： Kim SO,Choi BT,Choi IW,Cheong J,Kim GY,Kwon TK,Kim ND,Choi YH

更新日期：2009-10-31 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...

journal_title：BMB reports

authors： Shin HI,Chae KH,Cho TJ

更新日期：2013-10-01 00:00:00